Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis : A Network Perspective
Ong, Hui Lin (Universiteit van Amsterdam)
Isvoranu, Adela-Maria (Universiteit van Amsterdam)
Schirmbeck, Frederike (Arkin Institute for Mental Health (Amsterdam))
McGuire, Philip (King's College London. Department of Psychosis Studies)
Valmaggia, Lucia (King's College London)
Kempton, Matthew J. (King's College London)
van der Gaag, Mark (Vrije Universiteit Amsterdam)
Riecher-Rössler, Anita (Universität Basel)
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo)
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Nelson, Barnaby (The University of Melbourne)
Amminger, G. Paul (Orygen)
McGorry, Patrick (The University of Melbourne)
Pantelis, Christos (University of Melbourne & Melbourne Health)
Krebs, Marie-Odile (University of Paris)
Nordentoft, Merete (University of Copenhagen)
Glenthøj, Birte (University of Copenhagen)
Ruhrmann, Stephan (University of Cologne)
Sachs, Gabriele (Department of Psychiatry and Psychotherapy, Medical University of Vienna)
Rutten, Bart P. F. (Maastricht University Medical Centre)
van Os, Jim (Universiteit Utrecht)
de Haan, Lieuwe (Arkin Institute for Mental Health (Amsterdam))
Borsboom, Denny (Department of Psychology, Psychological Methods, University of Amsterdam)

Data:	2021
Resum:	The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.
Ajuts:	European Commission 241909
Nota:	Altres ajuts: Medical Research Council Fellowship (MR/J008915/1); Netherlands Organization for Scientific Research (406.16.516)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Network analysis ; Clinical high risk ; Psychosis ; Obsessive-compulsive ; Anxiety ; Depression ; Ultra-high risk
Publicat a:	Schizophrenia bulletin, Vol. 47 (february 2021) , p. 1018-1028, ISSN 1745-1701

DOI: 10.1093/schbul/sbaa187
PMID: 33595089

11 p, 6.6 MB

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