Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors
Serrano-Novillo, Clara (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
Oliveras, Anna (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
Ferreres Piñas, Joan Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Condom, Enric (Institut d'Investigació Biomèdica de Bellvitge)
Felipe, Antonio (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)

Date:	2020
Abstract:	Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling has been associated with neoplastic cell growth and cancer. Kv7 channels are expressed in blood vessels, and they participate in the maintenance of vascular tone and are implicated in myocyte proliferation. Although evidence links Kv7 remodeling to different types of cancer, its expression in vascular tumors has never been studied. Endothelium-derived vascular neoplasms range from indolent lesions to highly aggressive and metastasizing cancers. Here, we show that Kv7. 1 and Kv7. 5 are evenly distributed in tunicas as well as the endothelium of healthy veins and arteries. The layered structure of vessels is lost in vascular tumors. By studying eight vascular tumors with different origins and characteristics, we found that Kv7. 1 and Kv7. 5 expression was changed in vascular cancers. While both channels were generally downregulated, Kv7. 5 expression was clearly correlated with neoplastic malignancy. The vascular tumors did not contract; therefore, the role of Kv7 channels is probably related to proliferation rather than controlling vascular tone. Our results identify vascular Kv7 channels as targets for cancer detection and anticancer therapies.
Grants:	Agencia Estatal de Investigación BFU2017-87104-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Potassium channels ; Blood vessels ; Neoplasia ; Cancer
Published in:	International journal of molecular sciences, Vol. 21 (august 2020) , ISSN 1422-0067

DOI: 10.3390/ijms21176019
PMID: 32825637

13 p, 2.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles