Laminar Thickness Alterations in the Fronto-Parietal Cortical Mantle of Patients with Attention-Deficit/Hyperactivity Disorder
Hoekzema, Elseline (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Carmona, Susana (Harvard University. Harvard Social Cognition and Affective Neuroscience Lab)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Fernández, Vanesa Richarte (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Picado, Marisol (Institut Hospital del Mar d'Investigacions Mèdiques)
Bosch, Rosa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Soliva, Juan Carlos (Institut Hospital del Mar d'Investigacions Mèdiques)
Rovira, Mariana (CRC Corporació Sanitaria (Barcelona, Catalunya))
Vives, Yolanda (Institut de Física d'Altes Energies)
Bulbena Vilarrasa, Antonio (Institut de Neuropsiquiatria i Addiccions (INAD))
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Vilarroya Oliver, Óscar (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2012
Resum:	Although Attention-Deficit/Hyperactivity Disorder (ADHD) was initially regarded as a disorder exclusive to childhood, nowadays its prevalence in adulthood is well established. The development of novel techniques for quantifying the thickness of the cerebral mantle allows the further exploration of the neuroanatomical profiles underlying the child and adult form of the disorder. To examine the cortical mantle in children and adults with ADHD, we applied a vertex-wise analysis of cortical thickness to anatomical brain MRI scans acquired from children with (n = 43) and without ADHD (n = 41), as well as a group of adult neurotypical individuals (n = 31), adult patients with a history of stimulant treatment (n = 31) and medication-naïve adults with ADHD (n = 24). We observed several clusters of reduced laminar cortical thickness in ADHD patients in comparison to neurotypical individuals. These differences were primarily located in the dorsal attention network, including the bilateral inferior and superior parietal cortex and a section of the frontal cortex (centered on the superior frontal and precentral gyrus bilaterally). Further laminar thickness deficits were observed in the bilateral orbitofrontal cortex and medial occipital cortex. The deficits in the cortical surface were especially pronounced in the child sample, while adult patients showed a more typical laminar thickness across the cerebral mantle. These findings show that the neuroanatomical profile of ADHD, especially the childhood form of the disorder, involves robust alterations in the cortical mantle, which are most prominent in brain regions subserving attentional processing.
Ajuts:	Ministerio de Ciencia e Innovación SAF2009 -10901
Nota:	Aquest article té una correcció a 10.1371/annotation/7f26a4d8-ec45-4d43-a388-f2d0d4f1a76a
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 7 (December 2012) , art. e48286, ISSN 1932-6203

DOI: 10.1371/journal.pone.0048286
PMID: 23239964

10 p, 703.9 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut de Física d’Altes Energies (IFAE)
Articles > Articles de recerca
Articles > Articles publicats