Systemic profiles of micrornas, redox balance, and inflammation in lung cancer patients : influence of copd
Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques)
Guitart, Maria (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Curull Serrano, Víctor (Universitat Autònoma de Barcelona. Departament de Medicina)
Sánchez-Font, Albert (Institut Hospital del Mar d'Investigacions Mèdiques)
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Tang, Jun (Institut Hospital del Mar d'Investigacions Mèdiques)
Admetlló, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques)
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2021
Resum:	Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.
Ajuts:	Instituto de Salud Carlos III FIS 18/00075
Nota:	Altres ajuts: This study has been supported by Spanish Ministry of Science and Innovation, Sociedad Española de Neumología y Cirugía Torácica (SEPAR) 2018 & 2020.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	LC and COPD ; MicroRNAs ; Prooxidants and antioxidants ; GSH ; Inflammatory cytokines ; Associations between clinical and biological variables
Publicat a:	Biomedicines, Vol. 9 Núm. 10 (september 2021) , p. 1347, ISSN 2227-9059

DOI: 10.3390/biomedicines9101347
PMID: 34680465

16 p, 1.1 MB

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