Hunger and satiety peptides : is there a pattern to classify patients with prader-willi syndrome?
Bueno, Marta (Hospital Arnau de Vilanova (Lleida, Catalunya))
Boixadera Planas, Ester (Universitat Autònoma de Barcelona. Servei d'Estadística Aplicada)
Blanco Hinojo, Laura (Hospital del Mar (Barcelona, Catalunya))
Esteba-Castillo, Susanna (Parc Hospitalari Martí i Julià)
Giménez-Palop, Olga (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Torrents-Rodas, David (Philipps-Universität Marburg)
Pujol Nuez, Jesús (Hospital del Mar (Barcelona, Catalunya))
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Caixàs i Pedragós, Assumpta (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2021
Abstract:	Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27. 5 ± 8. 02 years; BMI 32. 4 ± 8. 14 kg/m), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 0, 30, 60 and 120. Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.
Grants:	Instituto de Salud Carlos III PI10/00940 Ministerio de Economía y Competitividad PI14/02057 Instituto de Salud Carlos III PI18/00734 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR2017/923
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Prader-Willi syndrome ; Obesity ; Hunger ; Satiety ; BDNF ; PYY ; Ghrelin ; Clusters
Published in:	Journal of clinical medicine, Vol. 10 Núm. 21 (11-1 2021) , p. 5170, ISSN 2077-0383

DOI: 10.3390/jcm10215170
PMID: 34768690

14 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles