Connexins in the Heart : Regulation, Function and Involvement in Cardiac Disease
Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Sánchez, Jose Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Valls-Lacalle, Laura (Universitat Autònoma de Barcelona. Departament de Medicina)
Consegal, Marta (Universitat Autònoma de Barcelona. Departament de Medicina)
Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2021
Resum:	Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes, allowing the existence of electrical coupling. However, in addition to this fundamental role, connexins are also involved in cardiomyocyte death and survival. Thus, chemical coupling through gap junctions plays a key role in the spreading of injury between connected cells. Moreover, in addition to their involvement in cell-to-cell communication, mounting evidence indicates that connexins have additional gap junction-independent functions. Opening of unopposed hemichannels, located at the lateral surface of cardiomyocytes, may compromise cell homeostasis and may be involved in ischemia/reperfusion injury. In addition, connexins located at non-canonical cell structures, including mitochondria and the nucleus, have been demonstrated to be involved in cardioprotection and in regulation of cell growth and differentiation. In this review, we will provide, first, an overview on connexin biology, including their synthesis and degradation, their regulation and their interactions. Then, we will conduct an in-depth examination of the role of connexins in cardiac pathophysiology, including new findings regarding their involvement in myocardial ischemia/reperfusion injury, cardiac fibrosis, gene transcription or signaling regulation.
Ajuts:	Instituto de Salud Carlos III PI17/01397
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Connexin ; Cx43 ; Gap junction ; Hemichannel ; Mitochondria ; Nucleus ; Heart ; Cardiomyocyte
Publicat a:	International journal of molecular sciences, Vol. 22 (april 2021) , ISSN 1422-0067

DOI: 10.3390/ijms22094413
PMID: 33922534

64 p, 3.2 MB

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