Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency
Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Núñez, Alexa (Universitat Autònoma de Barcelona)
Esquinas, Cristina (Universitat Autònoma de Barcelona)
Torres-Durán, María (Complexo Hospitalario Universitario de Vigo)
Rodriguez Hermosa, Juan Luis (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Calle Rubio, Myriam (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Tubio-Pérez, Ramón (Instituto de Investigación Sanitaria Galicia Sur)
Belmonte, Irene (Hospital Universitari Vall d'Hebron)
Rodríguez Frías, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Rodríguez, Esther (Hospital Universitari Vall d'Hebron)
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. A total of 148 AATD patients were included. Among these, 54. 7% were Pi*ZZ and 45. 3% were heterozygous for the Z allele. Between 4. 9% and 16. 5% of patients had abnormal liver enzymes, without differences among genotypes. Liver stiffness measurement (LSM) was significantly higher in Pi*ZZ individuals than in heterozygous Z (5. 6 vs. 4. 6 kPa; p = 0. 001). In total, in 8 (5%) individuals LSM was >7. 5 kPa, considered significant liver fibrosis, and ≥10 kPa in 3 (1. 9%) all being Pi*ZZ. Elevated liver enzymes were more frequently observed in patients with LSM > 7. 5 kPa, but in 5 out of 8 of these patients all liver enzymes were within normal range. In patients with AATD, the presence of abnormal liver enzymes is frequent; however, most of these patients do not present significant liver fibrosis. Transient elastography can help to identify patients with liver fibrosis even with normal liver enzymes and should be performed in all Z-allele carriers to screen for liver disease.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alpha1-antitrypsin deficiency ; Liver disease ; Transient elastography
Publicat a:	Journal of clinical medicine, Vol. 10 (april 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10081724
PMID: 33923569

13 p, 844.8 KB

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