Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
Bonkhoff, Anna K. (Massachusetts General Hospital (Boston))
Schirmer, Markus D. (University Hospital Bonn (Bonn, Alemanya))
Bretzner, Martin (Univ. Lille)
Hong, Sungmin (Massachusetts General Hospital (Boston))
Regenhardt, Robert W. (Massachusetts General Hospital (Boston))
Brudfors, Mikael (School of Biomedical Engineering & Imaging Sciences)
Donahue, Kathleen L. (Massachusetts General Hospital (Boston))
Nardin, Marco J. (Massachusetts General Hospital (Boston))
Dalca, Adrian Vasile (Massachusetts General Hospital (Boston))
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf)
Etherton, Mark R. (Massachusetts General Hospital (Boston))
Hancock, Brandon L. (Massachusetts General Hospital (Boston))
Mocking, Steven J. T. (Massachusetts General Hospital (Boston))
McIntosh, Elissa C. (Massachusetts General Hospital (Boston))
Attia, John (School of Medicine and Public Health)
Benavente, Oscar R. (University of British Columbia)
Bevan, Stephen (University of Lincoln)
Cole, John W. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System)
Donatti, Amanda (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN))
Griessenauer, Christoph J. (Research Institute of Neurointervention)
Heitsch, Laura (Washington University School of Medicine & Barnes-Jewish Hospital)
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia))
Jood, Katarina (Sahlgrenska University Hospital (Suècia))
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques)
Kittner, Steven J. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System)
Lemmens, Robin (University Hospitals Leuven (Bèlgica))
Levi, Christopher R. (John Hunter Hospital)
McDonough, Caitrin W. (University of Florida)
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica))
Phuah, Chia-Ling (Washington University School of Medicine)
Rolfs, Arndt (Centogene AG)
Ropele, Stefan (Medical University Graz)
Rosand, Jonathan (Massachusetts General Hospital (Boston))
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques)
Rundek, Tatjana (University of Miami)
Sacco, Ralph L. (University of Miami)
Schmidt, Reinhold (Medical University Graz)
Sharma, Pankaj (St Peter's and Ashford Hospitals)
Slowik, Agnieszka (Jagiellonian University Medical College)
Söderholm, Martin (Skåne University Hospital (Suècia))
Sousa, Alessandro (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN))
Stanne, Tara M. (the Sahlgrenska Academy at University of Gothenburg)
Strbian, Daniel (Helsinki University Hospital (Finlàndia))
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia))
Thijs, Vincent (Austin Health)
Vagal, Achala (University of Cincinnati College of Medicine)
Wasselius, Johan (Skåne University Hospital (Suècia))
Woo, Daniel (University of Cincinnati College of Medicine)
Zand, Ramin (Geisinger)
McArdle, Patrick F. (University of Maryland School of Medicine)
Worrall, Bradford B. (University of Virginia)
Jern, Christina (Sahlgrenska University Hospital (Suècia))
Lindgren, Arne G. (Lund University)
Maguire, Jane (University of Technology Sydney)
Bzdok, Danilo (Mila - Quebec Artificial Intelligence Institute)
Wu, Ona (Massachusetts General Hospital (Boston))
Rost, Natalia S. (Massachusetts General Hospital (Boston))
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke. Acute ischemic stroke impacts men and women differently. Here, the authors show how different lesion patterns in men and women are linked to the extent of stroke severity.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Brain ; Stroke
Publicat a:	Nature communications, Vol. 12 (june 2021) , ISSN 2041-1723

DOI: 10.1038/s41467-021-23492-3
PMID: 34078897

14 p, 3.0 MB

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