A smartphone sensor-based digital outcome assessment of multiple sclerosis
Montalban, Xavier (Hospital Universitari Vall d'Hebron)
Graves, Jennifer (University of California San Diego)
Midaglia, Luciana (Hospital Universitari Vall d'Hebron)
Mulero, P. (Hospital Universitari Vall d'Hebron)
Julian, Laura (Genentech (Estats Units d'Amèrica))
Baker, Michael (F. Hoffmann-La Roche (Suïssa))
Schadrack, Jan (F. Hoffmann-La Roche (Suïssa))
Gossens, Christian (F. Hoffmann-La Roche (Suïssa))
Ganzetti, Marco (F. Hoffmann-La Roche (Suïssa))
Scotland, Alf (F. Hoffmann-La Roche (Suïssa))
Lipsmeier, Florian (F. Hoffmann-La Roche (Suïssa))
van Beek, Johan (F. Hoffmann-La Roche (Suïssa))
Bernasconi, Corrado (F. Hoffmann-La Roche (Suïssa))
Belachew, Shibeshih (F. Hoffmann-La Roche (Suïssa))
Lindemann, Michael (F. Hoffmann-La Roche (Suïssa))
Hauser, Stephen L. (University of California)

Data:	2021
Resum:	Sensor-based monitoring tools fill a critical gap in multiple sclerosis (MS) research and clinical care. The aim of this study is to assess performance characteristics of the Floodlight Proof-of-Concept (PoC) app. In a 24-week study (clinicaltrials. gov: NCT02952911), smartphone-based active tests and passive monitoring assessed cognition (electronic Symbol Digit Modalities Test), upper extremity function (Pinching Test, Draw a Shape Test), and gait and balance (Static Balance Test, U-Turn Test, Walk Test, Passive Monitoring). Intraclass correlation coefficients (ICCs) and age- or sex-adjusted Spearman's rank correlation determined test-retest reliability and correlations with clinical and magnetic resonance imaging (MRI) outcome measures, respectively. Seventy-six people with MS (PwMS) and 25 healthy controls were enrolled. In PwMS, ICCs were moderate-to-good (ICC(2,1) = 0. 61-0. 85) across tests. Correlations with domain-specific standard clinical disability measures were significant for all tests in the cognitive (r = 0. 82, p < 0. 001), upper extremity function (|r|= 0. 40-0. 64, all p < 0. 001), and gait and balance domains (r = −0. 25 to −0. 52, all p < 0. 05; except for Static Balance Test: r = −0. 20, p > 0. 05). Most tests also correlated with Expanded Disability Status Scale, 29-item Multiple Sclerosis Impact Scale items or subscales, and/or normalized brain volume. The Floodlight PoC app captures reliable and clinically relevant measures of functional impairment in MS, supporting its potential use in clinical research and practice.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multiple sclerosis ; Smartphone ; Sensors ; Digital health technology ; Wearable electronic devices ; Mobile phone
Publicat a:	Multiple sclerosis, Vol. 28 (july 2021) , p. 654-664, ISSN 1477-0970

DOI: 10.1177/13524585211028561
PMID: 34259588

11 p, 1.5 MB

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