Norovirus outbreaks in long-term care facilities in Catalonia from 2017 to 2018
Parrón, Ignacio (Generalitat de Catalunya. Departament de Salut)
Barrabeig, Irene (Generalitat de Catalunya. Departament de Salut)
Alsedà, Miquel (Generalitat de Catalunya. Departament de Salut)
Rius i Gibert, Maria Cristina (Agència de Salut Pública de Barcelona)
Cornejo-Sánchez, Thais (Hospital Universitari Vall d'Hebron)
Jané i Checa, Mireia (Universitat de Barcelona. Departament de Medicina)
Pérez, Cristina (Generalitat de Catalunya. Departament de Salut)
Guix, Susana (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Domínguez, Ángela (Universitat de Barcelona. Departament de Salut Pública)
Working Group for the Study of Outbreaks of Acute Gastroenteritis in Catalonia
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Norovirus is the leading cause of outbreaks of acute viral gastroenteritis. We carried out this study to investigate outbreaks in long-term care facilities reported in 2017 and 2018 in Catalonia (Spain). The characteristics of the centers, exposed persons and the genogroups responsible were analyzed. Viral loads were estimated. The attack rate (AR) of the outbreaks studied, and the rate ratio (RR) and the odds ratio (OR) and their 95% confidence intervals as measures of association were calculated. The mean cycle thresholds were compared using the t-test for independent means. We included 30 outbreaks (4631 exposed people). The global AR was 25. 93%. The RR of residents vs. staff was 2. 28 (95% CI 2. 0-2. 6). The RR between AR in residents with total or severe dependence vs. residents with moderate, low or no-dependence was 1. 23 (95% CI 1. 05-1. 45). The AR were higher in smaller centers than in larger ones (38. 47% vs. 19. 25% and RR 2; 95% CI 1. 82-2. 2). GII was responsible for 70% of outbreaks. No association was found between the genogroup and presenting symptoms (OR 0. 96; 95% CI 0. 41-2. 26). Viral loads were higher in symptomatic than in asymptomatic patients (p = 0. 001).
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR 1342 Instituto de Salud Carlos III PI16-02005
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult ; Aged ; Aged, 80 and over ; Caliciviridae Infections ; Disease Outbreaks ; Female ; Gastroenteritis ; Humans ; Long-Term Care ; Male ; Middle Aged ; Norovirus ; Nursing Homes ; Prospective Studies ; Spain ; Young Adult
Publicat a:	Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 23218, ISSN 2045-2322

DOI: 10.1038/s41598-021-02348-2
PMID: 34853333

8 p, 1.1 MB

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