Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus : a proof-of-concept study
Maruccia, Federica (ICFO-Insitut de Ciències Fotòniques)
Tagliabue, Susanna (ICFO-Insitut de Ciències Fotòniques)
Fischer, Jonas B. (HemoPhotonics)
Kacprzak, Michał (Nalecz Institute of Biocybernetics and Biomedical Engineering)
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rosas, Katiuska (Hospital Universitari Vall d'Hebron)
Álvarez, Ignacio Delgado (Hospital Universitari Vall d'Hebron)
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona)
Durduran, Turgut (Institució Catalana de Recerca i Estudis Avançats)
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona)

Data:	2022
Resum:	Benign external hydrocephalus (BEH) is considered a self-limiting pathology with a good prognosis. However, some children present a pathological intracranial pressure (ICP) characterized by quantitative and qualitative alterations (the so-called B-waves) that can lead to neurological sequelae. Our purpose was to evaluate whether there were cerebral hemodynamic changes associated with ICP B-waves that could be evaluated with noninvasive neuromonitoring. We recruited eleven patients (median age 16 months, range 7 to 55 months) with BEH and an unfavorable evolution requiring ICP monitoring. Bedside, nocturnal monitoring using near-infrared time-resolved and diffuse correlation spectroscopies synchronized to the clinical monitoring was performed. By focusing on the timing of different ICP patterns that were identified manually by clinicians, we detected significant tissue oxygen saturation () changes () and blood flow index (BFI) variability () between regular and high-amplitude B-wave patterns. A blinded analysis looking for analogs of ICP patterns in BFI time traces achieved 90% sensitivity in identifying B-waves and 76% specificity in detecting the regular patterns. We revealed the presence of and BFI variations-detectable with optical techniques-during ICP B-waves in BEH children. Finally, the feasibility of detecting ICP B-waves in hemodynamic time traces obtained noninvasively was shown.
Ajuts:	European Commission. Horizon 2020 675332 European Commission. Horizon 2020 101017113 European Commission. Horizon 2020 101016087 Instituto de Salud Carlos III PI18/00468 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1380
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Benign enlargement of subarachnoid spaces ; Hydrocephalus ; Intracranial pressure monitoring ; Optical techniques ; Pathophysiology
Publicat a:	Neurophotonics, Vol. 9 (november 2022) , ISSN 2329-4248

DOI: 10.1117/1.NPh.9.4.045005
PMID: 36405998

21 p, 1.1 MB

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