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Página principal > Artículos > Artículos publicados > Association of Apolipoprotein e ϵ4 Allele with Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults with down Syndrome |
Fecha: | 2021 |
Resumen: | Importance: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the APOE ϵ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. Objective: To investigate the association of the APOE ϵ4 allele with clinical and multimodal biomarkers of AD in adults with DS. Design, Setting, and Participants: This dual-center cohort study recruited adults with DS in Barcelona, Spain, and in Cambridge, UK, between June 1, 2009, and February 28, 2020. Included individuals had been genotyped for APOE and had at least 1 clinical or AD biomarker measurement; 2 individuals were excluded because of the absence of trisomy 21. Participants were either APOE ϵ4 allele carriers or noncarriers. Main Outcomes and Measures: Participants underwent a neurological and neuropsychological assessment. A subset of participants had biomarker measurements: Aβ1-42, Aβ1-40, phosphorylated tau 181 (pTau181) and neurofilament light chain (NfL) in cerebrospinal fluid (CSF), pTau181, and NfL in plasma; amyloid positron emission tomography (PET); fluorine 18-labeled-fluorodeoxyglucose PET; and/or magnetic resonance imaging. Age at symptom onset was compared between APOE ϵ4 allele carriers and noncarriers, and within-group local regression models were used to compare the association of biomarkers with age. Voxelwise analyses were performed to assess topographical differences in gray matter metabolism and volume. Results: Of the 464 adults with DS included in the study, 97 (20. 9%) were APOE ϵ4 allele carriers and 367 (79. 1%) were noncarriers. No differences between the 2 groups were found by age (median [interquartile range], 45. 9 [36. 4-50. 2] years vs 43. 7 [34. 9-50. 2] years; P =. 56) or sex (51 male carriers [52. 6%] vs 199 male noncarriers [54. 2%]). APOE ϵ4 allele carriers compared with noncarriers presented with AD symptoms at a younger age (mean [SD] age, 50. 7 [4. 4] years vs 52. 7 [5. 8] years; P =. 02) and showed earlier cognitive decline. Locally estimated scatterplot smoothing curves further showed between-group differences in biomarker trajectories with age as reflected by nonoverlapping CIs. Specifically, carriers showed lower levels of the CSF Aβ1-42 to Aβ1-40 ratio until age 40 years, earlier increases in amyloid PET and plasma pTau181, and earlier loss of cortical metabolism and hippocampal volume. No differences were found in NfL biomarkers or CSF total tau and pTau181. Voxelwise analyses showed lower metabolism in subcortical and parieto-occipital structures and lower medial temporal volume in APOE ϵ4 allele carriers. Conclusions and Relevance: In this study, the APOE ϵ4 allele was associated with earlier clinical and biomarker changes of AD in DS. These results provide insights into the mechanisms by which APOE increases the risk of AD, emphasizing the importance of APOE genotype for future clinical trials in DS. |
Ayudas: | Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002/16/ 00408 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00119 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00125 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/95 Agencia Estatal de Investigación IJCI-2017-32609 Instituto de Salud Carlos III Pío del Río Hortega 98480 Instituto de Salud Carlos III CP18/00011 Instituto de Salud Carlos III GBHI ALZ UK-21-720973 Instituto de Salud Carlos III JR21-00018 Instituto de Salud Carlos III R01AG056031 Instituto de Salud Carlos III R01AG056531 Instituto de Salud Carlos III R01AG066870 Instituto de Salud Carlos III R21AG067549 Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI13/01532 Instituto de Salud Carlos III PI14/01126 Instituto de Salud Carlos III PI14/1561 Instituto de Salud Carlos III PI16/01825 Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III PI18/00327 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III PI18/00435 European Commission. Horizon 2020 2018-02532 European Research Council ALFGBG-720931 Ministerio de Economía y Competitividad CP20/00038 |
Nota: | Altres ajuts: Alzheimer's Strategic Fund; EU Joint Program for Neurodegenerative Disorders; Fundació "La Caixa"; Fundació Catalana Síndrome de Down and Fundació Víctor Grífols i Lucas; Marie Skłodowska-Curie (860197); Sisley D'Ornano Foundations (CM19/00017); Swedish State Support for Clinical Research (201809-2016862); Swedish government (ALFGBG-715986, JPND2019-466-236); National Institutes of Health (1R01AG056850-01A1, R01AG061566, R21AG056974); Alzheimer's Drug Discovery Foundation (ADSF-21-831376-C, ADSF-21-831377-C, ADSF-21-831381-C); Lowe Syndrome Association; Familjen Erling-Perssons Stiftelse (FO2019-0228); Fundació la Marató de TV3 (044412, 20141210); Stiftelsen för Gamla Tjänarinnor; Global Brain Health Institute (1913 Cycle 2019B); Medical Research Council (18HLT09); National Institute for Health Research; Health Foundation; Fondation Jérôme Lejeune; Alzheimer's Research UK; Hjärnfonden; Vetenskapsrådet (681712); European Regional Development Fund (FEDER); Alzheimerfonden (FO2017-0243); Collaboration for Leadership in Applied Health Research and Care - Greater Manchester; NIHR Collaboration for Leadership in Applied Health Research and Care South London ; UK Dementia Research Institute (2017-00915, AF-742881, RDAPB-201809-2016615) |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Adult ; Alleles ; Alzheimer Disease ; Amyloid beta-Peptides ; Apolipoprotein E4 ; Atrophy ; Biomarkers ; Cohort Studies ; Down Syndrome ; Female ; Glucose ; Heterozygote ; Hippocampus ; Humans ; Male ; Middle Aged ; Peptide Fragments ; Tau Proteins |
Publicado en: | JAMA Neurology, Vol. 78 Núm. 8 (august 2021) , p. 937-947, ISSN 2168-6157 |
11 p, 1.6 MB |