Divergent connectomic organization delineates genetic evolutionary traits in the human brain
Bueichekú, Elisenda (Harvard Medical School)
González-de-Echávarri, José María (Barcelonaβeta Brain Research Center (BBRC))
Ortiz-Teran, L. (righam and Women's Hospital (Boston, Estats Units d'Amèrica))
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau)
d'Oleire Uquillas, F. (Princeton Neuroscience Institute. Princeton University)
De Marcos, L. (Clínica Universidad de Navarra)
Orwig, W. (Harvard Medical School)
Kim, C.M. (Athinoula A. Martinos Center for Biomedical Imaging. Department of Radiology. Massachusetts General Hospital. Harvard Medical School)
Ortiz-Teran, E. (Universidad Rey Juan Carlos. Facultad de Ciencias Jurídicas y Sociales)
Basaia, Silvia (Neuroimaging Research Unit. San Raffaele Scientific Institute. Vita-Salute San Raffaele University)
Diez, I. (Athinoula A. Martinos Center for Biomedical Imaging. Department of Radiology. Massachusetts General Hospital. Harvard Medical School)
Sepulcre, J. (Athinoula A. Martinos Center for Biomedical Imaging. Department of Radiology. Massachusetts General Hospital. Harvard Medical School)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities-linked to Neuron Projection-were overrepresented cell traits. Homologue-orthologue comparisons using dN/dS-ratios bridged the gap between neurogenetic outcomes and biological data, summarizing the known evolutionary divergent pathways within the Homo Sapiens lineage. Evidence suggests that a crosstalk between functional specialization and information flow reflects putative biological qualities of brain architecture, such as neurite cellular functions like axonal or dendrite processes, hypothesized to have been selectively conserved in the species through positive selection. These findings expand our understanding of human brain function and unveil aspects of our cognitive trajectory in relation to our simian ancestors previously left unexplored.
Ayudas:	European Commission 2018 APOSTD
Nota:	Altres ajuts: National Institutes of Health (R01AG061811, R01AG061445); Ministerio de Educación, Cultura y Deporte (Estancias de movilidad en el extranjero "José Castillejo" para jóvenes doctores. Convocatoria 2017); Generalitat Valenciana.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Adult ; Biological Evolution ; Brain ; Brain Mapping ; Connectome ; Data Analysis ; Evolution, Molecular ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Quantitative Trait, Heritable ; Young Adult
Publicado en:	Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 19692, ISSN 2045-2322

DOI: 10.1038/s41598-021-99082-6
PMID: 34608211

11 p, 1.6 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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