Effect of altitude on mortality of end-stage renal disease patients on hemodialysis in Peru
Bravo-Jaimes, Katia (University of Texas Health Science Center at Houston)
Loescher, Viky Y. (Mount Sinai Hospital)
Canelo Aybar, Carlos Gilberto (Institut d'Investigació Biomèdica Sant Pau)
Rojas-Camayo, José (Instituto de Investigaciones de la Altura. Universidad Peruana Cayetano Heredia)
Mejia, Christian R. (School of Health Sciences. Universidad Continental. Huancayo)
Schult, Sandra (Instituto Nacional de Salud Del Niño)
Nieto, Ruben (EsSalud Cusco)
Singh, Kyra (University of Rochester Medical Center)
Messing, Susan (University of Rochester Medical Center)
Hinostroza, Juana (EsSalud. Centro Nacional de Salud Renal)

Fecha:	2021
Resumen:	Background: In Latin America, the prevalence of end-stage kidney disease (ESKD) has risen tremendously during the last decade. Previous studies have suggested that receiving dialysis at high altitude confers mortality benefits; however, this effect has not been demonstrated at >2000 m above sea level (masl) or in developing countries. Methods: This historical cohort study analyzed medical records from six Peruvian hemodialysis (HD) centers located at altitudes ranging from 44 to 3827 masl. Adult ESKD patients who started maintenance HD between 2000 and 2010 were included. Patients were classified into two strata based on the elevation above sea level of their city of residence: low altitude (<2000 masl) and high altitude (≥2000 masl). Death from any cause was collected from national registries and Cox proportional hazards models were built. Results: A total of 720 patients were enrolled and 163 (22. 6%) resided at high altitude. The low-Altitude group was significantly younger, more likely to have diabetes or glomerulonephritis as the cause of ESKD and higher hemoglobin. The all-cause mortality rate was 84. 3 per 1000 person-years. In the unadjusted Cox model, no mortality difference was found between the high-and low-Altitude groups {hazard ratio [HR] 1. 20 [95% confidence interval (CI) 0. 89-1. 62]}. After multivariable adjustment, receiving HD at high altitude was not significantly associated with higher mortality, but those with diabetes as the cause of ESKD had significantly higher mortality [HR 2. 50 (95% CI 1. 36-4. 59)]. Conclusions: In Peru, patients receiving HD at high altitudes do not have mortality benefits.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Altitude ; Anemia ; Chronic hemodialysis ; Chronic hypoxia ; Mortality
Publicado en:	Clinical Kidney Journal, Vol. 14 Núm. 3 (january 2021) , p. 998-1003, ISSN 2048-8513

DOI: 10.1093/ckj/sfaa056
PMID: 33777381

6 p, 585.0 KB

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