Impact of Age on the Effectiveness and Safety of Insulin Glargine 300 U/mL : Results from the REALI European Pooled Data Analysis
Bonadonna, Riccardo C (University of Parma)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Müller-Wieland, Dirk (University Hospital Aachen (Alemanya))
Freemantle, Nick (University College London)
Bigot, Gregory (IVIDATA Group)
Mauquoi, Celine (International Drug Development Institute (IDDI))
Ciocca, Alice (Sanofi)
Bonnemaire, Mireille (Sanofi)
Gourdy, Pierre (Université de Toulouse)

Fecha:	2021
Resumen:	Introduction: Patients aged ≥ 65 years continue to be underrepresented in clinical studies related to type 2 diabetes mellitus (T2DM). Accordingly, the REALI pooled analysis was performed to evaluate the effectiveness and safety of insulin glargine 300 U/mL (Gla-300) across different age subgroups, using data from 14 interventional and non-interventional studies. Methods: Pooled efficacy and safety data were collected from 8106 European patients with uncontrolled T2DM who were initiated on or switched to Gla-300 injected once daily for 24 weeks. Patients were categorised into five age subgroups: < 50 (N = 727), 50-59 (N = 2030), 60-69 (N = 3054), 70-79 (N = 1847) and ≥ 80 years (N = 448). Results: Mean baseline haemoglobin A1c (HbA1c) decreased linearly from the youngest (9. 10%) to the oldest (8. 46%) age subgroup. Following Gla-300 initiation, there were similar HbA1c reductions across age groups, with a least squares mean (95% confidence interval) change in HbA1c from baseline to week 24 of − 1. 09% (− 1. 18 to − 1. 00), − 1. 08% (− 1. 14 to − 1. 03), − 1. 12% (− 1. 17 to − 1. 07), − 1. 18% (− 1. 24 to − 1. 12) and − 1. 11% (− 1. 23 to − 0. 99) in the < 50, 50-59, 60-69, 70-79 and ≥ 80 years subgroups, respectively. The incidences and event rates of reported hypoglycaemia were overall low. Compared to younger age subgroups, lower incidences of symptomatic hypoglycaemia occurring at any time of the day (5. 9 vs. 7. 6-9. 4% for the younger subgroups) or during the night (0. 5 vs. 1. 6-2. 5%) were recorded in patients aged ≥ 80 years. By contrast, the highest incidence of severe hypoglycaemia occurring any time of the day was reported in the subgroup aged ≥ 80 years (1. 1 vs. 0. 1-0. 6% for the younger age subgroups). Conclusion: Gla-300 initiated in patients with uncontrolled T2DM provides glycaemic improvement with a favourable safety profile across a wide range of ages.
Nota:	Altres ajuts: Sanofi (Paris, France).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Age ; Europe ; Glycaemic control ; Hypoglycaemia ; Insulin glargine 300 U/mL ; Older adults ; Pooled analysis ; Type 2 diabetes
Publicado en:	Diabetes Therapy, Vol. 12 Núm. 4 (april 2021) , p. 1073-1097, ISSN 1869-6961

DOI: 10.1007/s13300-021-01030-0
PMID: 33650085

25 p, 618.2 KB

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