Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis
Calvi, Alberto (University College London)
Clarke, Margareta A. (Hospital Universitari Vall d'Hebron)
Prados Carrasco, Ferran (University College London)
Chard, Declan (University College London)
Ciccarelli, Olga (University College London)
Alberich, Manel (Hospital Universitari Vall d'Hebron)
Pareto, Deborah (Hospital Universitari Vall d'Hebron)
Rodríguez Barranco, Marta (Hospital Universitari Vall d'Hebron)
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron)
Tur, Carmen (Hospital Universitari Vall d'Hebron)
Rovira, Alex (Hospital Universitari Vall d'Hebron)
Barkhof, Frederik (University College London)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). To identify the relationship between SELs and PRLs in MS, and their association with disability. 61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs. The median follow-up time was 3. 2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, p = 0. 027). PRL counts positively correlated with SEL counts (ρ= 0. 28, p = 0. 03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0. 15/year, 95% confidence interval (0. 04, 0. 27), p = 0. 009) than SEL+PRL-patients. SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic active lesions ; Paramagnetic rim lesions (PRLs) ; Slowly expanding lesions (SELs) ; Volumetric MRI ; Susceptibility-weighted imaging (SWI) ; Multiple sclerosis
Publicat a:	Multiple sclerosis, Vol. 29 (december 2022) , p. 352-362, ISSN 1477-0970

DOI: 10.1177/13524585221141964
PMID: 36515487

11 p, 844.8 KB

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