Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors
Alejos, Belén (Centro Nacional de Epidemiología (Espanya))
Suárez-García, Inés (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Bisbal, Otilia (Hospital Universitario 12 de Octubre (Madrid))
Iribarren, José Antonio (Hospital de Donostia (Sant Sebastià, País Basc))
Asensi, Víctor (Hospital Universitario Central de Asturias)
Górgolas, Miguel (Hospital Universitario Fundación Jiménez Díaz)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Moreno, Santiago (Hospital Universitario Ramón y Cajal (Madrid))
Jarrin, Inma (Centro Nacional de Epidemiología (Espanya))
CoRIS, Cohort

Data:	2019
Resum:	Background We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. Methods We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. Results Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32. 1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14. 9%), TDF/FTC/rilpivirine (RPV) (14. 0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13. 7%), TDF/FTC+DTG (10. 0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9. 8%) and TDF/FTC+raltegravir (RAL) (5. 6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100. 000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100. 000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4 Conclusions The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location.
Ajuts:	Instituto de Salud Carlos III RD06/006 Instituto de Salud Carlos III RD12/0017/0018 Instituto de Salud Carlos III RD16/0002/0006
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	SDG 3 - Good Health and Well-being
Publicat a:	PloS one, Vol. 14 Núm. 8 (2019) , art. e0221598, ISSN 1932-6203

DOI: 10.1371/journal.pone.0221598
PMID: 31449566

12 p, 745.4 KB

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