Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens
Kwon, Jung-Hoon (Kyungpook National University)
Bertran, Kateri (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Lee, Dong-Hun (Konkuk University)
Criado, Miria Ferreira (Auburn University)
Killmaster, Lindsay (U.S. National Poultry Research Center)
Pantin-Jackwood, Mary J. (U.S. National Poultry Research Center)
Swayne, David E. (U.S. National Poultry Research Center)

Data:	2023
Resum:	Clade 2. 3. 4. 4 Eurasian lineage H5Nx highly pathogenic avian influenza virus (HPAIV) has become the globally dominant clade and caused global outbreaks since 2014. The clade 2. 3. 4. 4 viruses have evolved into eight hemagglutinin subgroups (2. 3. 4. 4a-h). In this study, we evaluated the infectivity, pathobiology, and transmissibility of seven clade 2. 3. 4. 4 viruses (two 2. 3. 4. 4a, two 2. 3. 4. 4b, one 2. 3. 4. 4c and two 2. 3. 4. 4e) in chickens. The two clade 2. 3. 4. 4e viruses caused 100% mortality and transmissibility in chickens. However, clade 2. 3. 4. 4a and c viruses showed 80-90% mortality and 67% transmissibility. Clade 2. 3. 4. 4b viruses showed 100% mortality, but no transmission to co-housed chickens was observed based on lack of seroconversion. All the infected chickens died showing systemic infection, irrespective of subgroup. The results highlight that all the clade 2. 3. 4. 4 HPAIVs used in this study caused high mortality in infected chickens, but the transmissibility of the viruses in chickens was variable in contrast to that of previous Eurasian-lineage H5N1 HPAIVs. Changes in the pathogenicity and transmissibility of clade 2. 3. 4. 4 HPAIVs warrant careful monitoring of the viruses to establish effective control strategies.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Avian influenza virus ; Highly pathogenic avian influenza virus ; Clade 2.3.4.4 ; Infectivity ; Pathogenicity ; Transmissibility ; Chicken
Publicat a:	Emerging microbes & infections, Vol. 12 (june 2023) , ISSN 2222-1751

DOI: 10.1080/22221751.2023.2218945
PMID: 37309051

10 p, 1.9 MB

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