Immunosenescence in multiple sclerosis : the identification of new therapeutic targets
Dema, María (Hospital Universitari Vall d'Hebron)
Eixarch, Herena (Hospital Universitari Vall d'Hebron)
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid))
Montalban, Xavier (Hospital Universitari Vall d'Hebron)
Espejo, Carmen (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The number of elderly multiple sclerosis (MS) patients is growing, mainly due to the increase in the life expectancy of the general population and the availability of effective disease-modifying treatments. However, current treatments reduce the frequency of relapses and slow the progression of the disease, but they cannot stop the disability accumulation associated with disease progression. One possible explanation is the impact of immunosenescence, which is associated with the accumulation of unusual immune cell subsets that are thought to have a role in the development of an early ageing process in autoimmunity. Here, we provide a recent overview of how senescence affects immune cell function and how it is involved in the pathogenesis of autoimmune diseases, particularly MS. Numerous studies have demonstrated age-related immune changes in experimental autoimmune encephalomyelitis models, and the premature onset of immunosenescence has been demonstrated in MS patients. Therefore, potential therapeutic strategies based on rejuvenating the immune system have been proposed. Senolytics and regenerative strategies using haematopoietic stem cells, therapies based on rejuvenating oligodendrocyte precursor cells, microglia and monocytes, thymus cells and senescent B and T cells are capable of reversing the process of immunosenescence and could have a beneficial impact on the progression of MS.
Grants:	Instituto de Salud Carlos III PI18/01146
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Immunosenescence ; Ageing ; Autoimmunity ; Multiple sclerosis
Published in:	Autoimmunity Reviews, Vol. 20 Núm. 9 (september 2021) , p. 102893, ISSN 1873-0183

DOI: 10.1016/j.autrev.2021.102893
PMID: 34237417

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