Is asthma control more than just an absence of symptoms? : An expert consensus statement
Canonica, G. Walter (Humanitas University)
Spanevello, Antonio (Università degli Studi dell'Insubria. Dipartimento di Medicina e Chirurgia)
Pérez de Llano, Luis (Instituto de Investigación Sanitaria Santiago de Compostela)
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Blakey, John D. (Curtin University of Technology)
Garcia, Gabriel (Hospital R. Rossi. Servicio de Neumología (Argentina))
Inoue, Hiromasa (Kagoshima University. Department of Pulmonary Medicine)
Dalcolmo, Margareth (Fundação Oswaldo Cruz (Brazil))
Yang, Dong (Fudan University. Zhongshan Hospital (China))
Mokashi, Soniya (GSK Brentford (UK))
Kurne, Abhishek (Global Medical Affairs (Singapore))
Butta, Aman Kapil (GSK (Singapore))
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	PURPOSE: Definitions and measures of asthma control used in clinical trials and in clinical practice vary considerably. There is also misalignment between patients and healthcare professionals (HCPs) in terms of understanding and managing asthma control. This study aimed to progress towards a consensus definition of asthma control, and evaluate disparities between HCP and patient perspectives. BASIC PROCEDURES: A two-stage Delphi questionnaire involving asthma specialists sought to identify areas of consensus on aspects of asthma control in clinical practice. Results were compared with those of a structured literature review to assess if existing guidance and measures of asthma control used in studies correlated with practice. Eighty-two panelists took part in the Delphi questionnaire. The structured literature review included 185 manuscripts and 31 abstracts. MAIN FINDINGS: Panelists agreed that there was no standard definition of asthma control, confirmed by a total of 19 different composite consensus/guideline definitions and/or validated measures of control being identified across the Delphi study and literature review. Panelists agreed on the positive associations of well-controlled asthma with patient outcomes, but not on the components or thresholds of a working definition of control. PRINCIPAL CONCLUSIONS: A universally accepted definition and measure of asthma control that is utilized and understood by patients, HCPs, and researchers is required.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Asthma control ; Symptom control ; Exacerbations ; Delphi consensus ; Asthma ; Quality of life
Published in:	Respiratory Medicine, Vol. 202 (October 2022) , art. 106942, ISSN 1532-3064

DOI: 10.1016/j.rmed.2022.106942
PMID: 36096072

9 p, 461.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles