Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment
German-Cortés, Júlia (Hospital Universitari Vall d'Hebron)
Vilar-Hernández, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Andrade, Fernanda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment. Nanotechnology has helped to address these questions, making important contributions in the oncological field. The use of nanoparticles has allowed the improvement of the therapeutic index of several conventional drugs and facilitates the tumoral accumulation and intracellular delivery of complex biomolecules, such as genetic material. Among the wide range of nanotechnology-based drug delivery systems (nanoDDS), solid lipid nanoparticles (SLNs) have emerged as promising systems for delivering different types of cargo. Their solid lipid core, at room and body temperature, provides SLNs with higher stability than other formulations. Moreover, SLNs offer other important features, namely the possibility to perform active targeting, sustained and controlled release, and multifunctional therapy. Furthermore, with the possibility to use biocompatible and physiologic materials and easy scale-up and low-cost production methods, SLNs meet the principal requirements of an ideal nanoDDS. The present work aims to summarize the main aspects related to SLNs, including composition, production methods, and administration routes, as well as to show the most recent studies about the use of SLNs for cancer treatment.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cancer therapy ; Cancer diagnostics ; Drug delivery ; Nanomedicine ; Solid lipid nanoparticles ; Targeted therapy
Publicat a:	Pharmaceutics, Vol. 15 (march 2023) , ISSN 1999-4923

DOI: 10.3390/pharmaceutics15030831
PMID: 36986692

28 p, 3.4 MB

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