Liver transplantation in metastatic colorectal cancer : are we ready for it?
Ros Montañá, Javier (Vall d'Hebron Institut d'Oncologia)
Salva, Francesc (Vall d'Hebron Institut d'Oncologia)
Dopazo, Cristina (Hospital Universitari Vall d'Hebron)
López, Daniel (Vall d'Hebron Institut d'Oncologia)
Saoudi, Nadia (Vall d'Hebron Institut d'Oncologia)
Baraibar, Iosune (Vall d'Hebron Institut d'Oncologia)
Charco, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia)
Elez, Elena (Vall d'Hebron Institut d'Oncologia)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Colorectal cancer ; Surgical oncology
Published in:	British Journal of Cancer, Vol. 128 (march 2023) , p. 1797-1806, ISSN 1532-1827

DOI: 10.1038/s41416-023-02213-1
PMID: 36879000

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