Liver transplantation in metastatic colorectal cancer : are we ready for it?
Ros Montañá, Javier ![ORCID Identifier](/img/uab/orcid.ico)
(Vall d'Hebron Institut d'Oncologia)
Salva, Francesc ![ORCID Identifier](/img/uab/orcid.ico)
(Vall d'Hebron Institut d'Oncologia)
Dopazo, Cristina ![ORCID Identifier](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
López, Daniel (Vall d'Hebron Institut d'Oncologia)
Saoudi, Nadia (Vall d'Hebron Institut d'Oncologia)
Baraibar, Iosune ![ORCID Identifier](/img/uab/orcid.ico)
(Vall d'Hebron Institut d'Oncologia)
Charco, Ramon
(Hospital Universitari Vall d'Hebron. Institut de Recerca)
Tabernero, Josep
(Vall d'Hebron Institut d'Oncologia)
Elez, Elena
(Vall d'Hebron Institut d'Oncologia)
Universitat Autònoma de Barcelona
Date: |
2023 |
Abstract: |
Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting. |
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Colorectal cancer ;
Surgical oncology |
Published in: |
British journal of cancer, Vol. 128 (march 2023) , p. 1797-1806, ISSN 1532-1827 |
DOI: 10.1038/s41416-023-02213-1
PMID: 36879000
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Record created 2023-08-01, last modified 2024-05-28