Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk
Consegal, Marta (Hospital Universitari Vall d'Hebron)
Barba, Ignasi (Hospital Universitari Vall d'Hebron)
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron)
Otaegui, Imanol (Hospital Universitari Vall d'Hebron)
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron)
Martí Balaguer, Gerard (Hospital Universitari Vall d'Hebron)
Serra-Vidal, Bernat (Hospital Universitari Vall d'Hebron)
Bellera Gotarda, Neus (Hospital Universitari Vall d'Hebron)
Ojeda-Ramos, Manuel (Hospital Universitari Vall d'Hebron)
Valente, Filipa (Hospital Universitari Vall d'Hebron)
Carmona, Maria Ángeles (Hospital Universitari Vall d'Hebron)
Miró-Casas, Elisabet (Hospital Universitari Vall d'Hebron)
Sambola, Antonia (Hospital Universitari Vall d'Hebron)
Lidón, Rosa María (Hospital Universitari Vall d'Hebron)
Bañeras, Jordi (Hospital Universitari Vall d'Hebron)
Barrabés, José A (Hospital Universitari Vall d'Hebron)
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Benito, Begoña (Hospital Universitari Vall d'Hebron)
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron)
Inserte Igual, Javier (Hospital Universitari Vall d'Hebron)
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron)
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs submitted to transient coronary occlusion. Succinate levels might have a prognostic value, as they may correlate with edema volume or myocardial infarct size. However, blood from the coronary sinus is not routinely obtained in the CathLab. As succinate might be also increased in peripheral blood, we aimed to investigate whether peripheral plasma concentrations of succinate and other metabolites obtained during coronary revascularization correlate with edema volume or infarct size in STEMI patients. Plasma samples were obtained from peripheral blood within the first 10 min of revascularization in 102 STEMI patients included in the COMBAT-MI trial (initial TIMI 1) and from 9 additional patients with restituted coronary blood flow (TIMI 2). Metabolite concentrations were analyzed by 1 H-NMR. Succinate concentration averaged 0. 069 ± 0. 0073 mmol/L in patients with TIMI flow ≤ 1 and was significantly increased in those with TIMI 2 at admission (0. 141 ± 0. 058 mmol/L, p < 0. 05). However, regression analysis did not detect any significant correlation between most metabolite concentrations and infarct size, extent of edema or other cardiac magnetic resonance (CMR) variables. In conclusion, spontaneous reperfusion in TIMI 2 patients associates with enhanced succinate levels in peripheral blood, suggesting that succinate release increases overtime following reperfusion. However, early plasma levels of succinate and other metabolites obtained from peripheral blood does not correlate with the degree of irreversible injury or area at risk in STEMI patients, and cannot be considered as predictors of CMR variables. Trial registration: Registered at (NCT02404376) on 31/03/2015. EudraCT number: 2015-001000-58.
Ayudas:	Instituto de Salud Carlos III PI17/01397
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cardiovascular biology ; Diagnostic markers ; Prognostic markers
Publicado en:	Scientific reports, Vol. 13 (april 2023) , ISSN 2045-2322

DOI: 10.1038/s41598-023-34196-7
PMID: 37106099

7 p, 1000.2 KB

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