The use of lumbar puncture and safety recommendations in Alzheimer's disease : a plain language summary
Hampel, Harald (Eisai Inc. Neurology Business Group)
Elhage, Aya (Eisai Inc. Neurology Business Group)
Shaw, Leslie M. (Perelman School of Medicine. Department of Pathology & Laboratory Medicine. University of Pennsylvania)
Aisen, Paul (Usc Alzheimer's Therapeutic Research Institute)
Chen, Christopher (Memory Aging & Cognition Centre. Departments of Pharmacology & Psychological Medicine. Yong Loo Lin School of Medicine. National University of Singapore)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Iwatsubo, Takeshi (Department of Neuropathology. Graduate School of Medicine. The University of Tokyo)
Iwata, Atsushi (Tokyo Metropolitan Geriatric Hospital)
Yamada, Masahito (Department of Neurology & Neurological Science. Tokyo Medical & Dental University)
Ikeuchi, Takeshi (Department of Molecular Genetics. Brain Research Institute. Niigata University)
Jia, Jianping (Innovation Center for Neurological Disorders. Department of Neurology. Xuan Wu Hospital. Capital Medical University)
Wang, Huali (Dementia Care & Research Center. Peking University Institute of Mental Health (Sixth Hospital). Beijing Dementia Key Lab. National Clinical Research Center for Mental Disorders)
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC))
Peskind, Elaine (Va Northwest Mental Illness Research. Education & Clinical Center. Va Puget Sound Health Care System. Department of Psychiatry & Behavioral Sciences. University of Washington School of Medicine)
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital)
Cummings, Jeffrey (Chambers-Grundy Center for Transformative Neuroscience. Department of Brain Health. School of Integrated Health Sciences. University of Nevada Las Vegas (UNLV))
Vergallo, Andrea (Eisai Inc. Neurology Business Group)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	What is this summary about? This is a plain language summary of an article published in Alzheimer's & Dementia. It looks at a type of test called a lumbar puncture (also known as spinal tap) used in people suspected of having Alzheimer's disease or some other form of dementia. This summary focuses on how to do a lumbar puncture safely. Why is this important? Alzheimer's disease is a progressive condition, which means it gets worse over time. This leads to difficulties with thinking and memory. People with Alzheimer's disease show a build up of proteins called amyloid-β and tau in the brain. This is followed by a gradual loss of brain cells and brain function. The changes in the brain are thought to occur years before symptoms appear. Lumbar puncture is a medical procedure during which samples of cerebrospinal fluid are collected. In Alzheimer's disease, it is used to examine cerebrospinal fluid biomarkers that can help diagnose disease. Lumbar puncture is traditionally considered as a painful and invasive procedure with frequent side effects. However, multiple studies indicate that a lumbar puncture can be performed safely. Side effects are typically mild and do not require specialist intervention. What are the key takeaways? Despite the low risk of serious complications associated with a lumbar puncture, physicians and their patients may be reluctant to recommend or undergo this procedure. Patient education, specialist training, as well as new methods concerning patient safety are important factors to support the widespread use of lumbar puncture in Alzheimer's disease. </sec.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Neurodegenerative Disease Management, Vol. 12 Núm. 5 (january 2022) , p. 221-229, ISSN 1758-2032

DOI: 10.2217/nmt-2022-0012
PMID: 35866715

9 p, 1.5 MB

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