Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease
Graterol Torres, Fredzzia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Molina, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Soler-Majoral, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Romero-González, Gregorio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez Chitiva, Néstor (Institut Germans Trias i Pujol)
Troya-Saborido, Maribel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Socias Rullan, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Burgos, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Paúl Martínez, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Urrutia Jou, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cañameras, Carles (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Riera Sadurní, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vila, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	While patient care, kidney replacement therapy, and transplantation techniques for chronic kidney disease (CKD) have continued to progress, the incidence of malnutrition disorders in CKD appears to have remained unchanged over time. However, there is now a better understanding of the underlying pathophysiology according to the disease background, disease stage, and the treatment received. In CKD patients, the increased production of proinflammatory cytokines and oxidative stress lead to a proinflammatory milieu that is at least partially responsible for the increased morbidity and mortality in this patient population. New insights into the pathogenic role of innate immunity and the proinflammatory cytokine profile, characterized, for instance, by higher levels of IL-6 and TNF-α, explain some of the clinical and laboratory abnormalities observed in these patients. In this article, we will explore currently available nutritional-inflammatory biomarkers in distinct CKD populations (hemodialysis, peritoneal dialysis, transplantation) with a view to evaluating their efficacy as predictors of malnutrition and their involvement in the common proinflammatory process. Although there is a direct relationship between inflammatory-nutritional status, signs and symptoms [e. g. , protein-energy wasting (PEW), anorexia], and comorbidities (e. g. , atheromatosis, atherosclerosis), we are in need of clearly standardized markers for nutritional-inflammatory assessment to improve their performance and design appropriate bidirectional interventions.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chronic kidney disease ; CKD ; Cytokines ; Inflammation ; Malnutrition ; Malnutrition inflammation cachexia syndrome ; Malnutrition-inflammation score ; MIS ; MICS ; Proinflammatory cytokines ; Protein-energy wasting ; Sarcopenia
Publicado en:	Nutrients, Vol. 14 (october 2022) , ISSN 2072-6643

DOI: 10.3390/nu14204297
PMID: 36296981

10 p, 474.6 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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