A novel integrated platform enabling simultaneous microextraction and chemical analysis on-chip
Santigosa-Murillo, Elia (Universitat Autònoma de Barcelona. Departament de Química Analítica)
Moreno, Alexandre (Institut de Microelectrònica de Barcelona)
Ramos-Payán, María (Universidad de Sevilla. Departamento de Química Analítica)
Ríos, Juan Manuel (Institut de Microelectrònica de Barcelona)
Muñoz Berbel, Xavier (Institut de Microelectrònica de Barcelona)
Muñoz, María (Universitat Autònoma de Barcelona. Departament de Química Analítica)
Giménez-Gómez, Pablo (Institut de Microelectrònica de Barcelona)

Data:	2023
Resum:	The nature and size of biological, pharmaceutical or environmental analytes complicates their extraction and detection outside of laboratories and near the site of interest by the current chromatographic methods because they require the combination of bulky extraction and detection methods. In order to solve this inefficient centralized control, a ground-breaking and miniaturized proof of concept platform is developed in this work. The platform integrates for the very first time an electro-membrane extraction process and an accurate analyte quantification method in the same device, by using electrochemical impedance spectroscopy (EIS) as analytical technique. The microfluidic flow cell, including the microfluidic components, is fabricated in polymeric materials by rapid prototyping techniques. It comprises a four-electrode platinum thin-film chip that enables the control of the microextraction and the full characterization of the process, i. e. , extraction efficiency determination, at the same time. The microfluidic system has been simulated by using computational tools, enabling an accurate prediction of the effect of the different experimental conditions in the microextraction efficiency. The platform has been validated in the microextraction of the nonsteroidal anti-inflammatory drug ketoprofen in a range from 0. 5 ppm to 6 ppm. The predicted microextraction efficiency values obtained by EIS were compared with those calculated from the high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD), showing an excellent agreement. This validates the high potential of this integrated and miniaturized platform for the simultaneous extraction by electro-membrane and also the analysis within the platform, solving one of the of most important limitations of current systems.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-329 Agencia Estatal de Investigación PRE2019-088338 Agencia Estatal de Investigación PID2021-127653NB-C21 Agencia Estatal de Investigación RTI2018-101974-B-C-21
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Electromembrane microextraction ; Electrochemical impedance spectroscopy detection ; Biological pharmaceutical or environmental analytes detection ; Thin-film microelectrodes
Publicat a:	Microchemical Journal, Vol. 193 (October 2023) , art. 109044, ISSN 0026-265X

DOI: 10.1016/j.microc.2023.109044

10 p, 6.3 MB

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