The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli
Porta-Casteràs, Daniel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Cano, Marta (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Steward, Trevor (University of Melbourne)
Andero Galí, Raül (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2022
Abstract:	Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53. 4% female). Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology.
Grants:	Instituto de Salud Carlos III FI19/00251 Ministerio de Economía y Competitividad RYC2014-15784 Ministerio de Economía y Competitividad SAF2016-76565-R Agencia Estatal de Investigación PID2020-112705RB-I00 Instituto de Salud Carlos III AC19/00077 Instituto de Salud Carlos III AC19/00088
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	PACAP ; Fmri ; Hippocampus ; Women ; Threat ; PTSD
Published in:	Neurobiology of Stress, Vol. 18 (april 2022) , ISSN 2352-2895

DOI: 10.1016/j.ynstr.2022.100448
PMID: 35685680

7 p, 2.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles