The human cell count and size distribution
Hatton, Ian a. (McGill University. Department of Earth and Planetary Sciences)
Galbraith, Eric (Institució Catalana de Recerca i Estudis Avançats)
Cyrille Merleau, Nono Shaha (University of Leipzig. Center for Scalable Data Analytics and Artificial Intelligence)
Miettinen, Teemu (Massachusetts Institute of Technology)
Smith, Benjamin mcdonald (Columbia University Medical Center. Department of Medicine)
Shander, Jeffery (Independent Researcher and Consultant)

Data:	2023
Resum:	Cell size and cell count are adaptively regulated and intimately linked to growth and function. Yet, despite their widespread relevance, the relation between cell size and count has never been formally examined over the whole human body. Here, we compile a comprehensive dataset of cell size and count over all major cell types, with data drawn from >1,500 published sources. We consider the body of a representative male (70 kg), which allows further estimates of a female (60 kg) and 10-y-old child (32 kg). We build a hierarchical interface for the cellular organization of the body, giving easy access to data, methods, and sources (https://humancelltreemap. mis. mpg. de/). In total, we estimate total body counts of ≈36 trillion cells in the male, ≈28 trillion in the female, and ≈17 trillion in the child. These data reveal a surprising inverse relation between cell size and count, implying a trade-off between these variables, such that all cells within a given logarithmic size class contribute an equal fraction to the body's total cellular biomass. We also find that the coefficient of variation is approximately independent of mean cell size, implying the existence of cell-size regulation across cell types. Our data serve to establish a holistic quantitative framework for the cells of the human body, and highlight large-scale patterns in cell biology.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cell biomass ; Cell count ; Cell size ; Size distribution ; Size homeostasis
Publicat a:	Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Issue 39 (September 2023) , art. e2303077120, ISSN 1091-6490

DOI: 10.1073/pnas.2303077120
PMID: 37722043

10 p, 4.5 MB

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