Rationale and design of the hip fracture accelerated surgical treatment and care track (hip attack) trial : A protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients
Borges, Flavia K. (Population Health Research Institute)
Bhandari, Mohit (McMaster University (Canadà))
Patel, Ameen (McMaster University (Canadà))
Avram, Victoria (McMaster University (Canadà))
Guerra-Farfán, Ernesto (Hospital Universitari Vall d'Hebron)
Sigamani, Alben (Narayana Health)
Umer, Masood (Aga Khan University)
Tiboni, Maria (McMaster University (Canadà))
Adili, Anthony (McMaster University (Canadà))
Neary, John (McMaster University (Canadà))
Tandon, Vikas (McMaster University (Canadà))
Sancheti, Parag K. (Sancheti Institute for Orthopaedics and Rehabilitation (Pune, Índia))
Lawendy, AbdelRahman (London Health Sciences Centre)
Jenkinson, Richard (University of Toronto)
Ramokgopa, Mmampapatla (University of the Witwatersrand)
Biccard, Bruce M (University of Cape Town)
Szczeklik, Wojciech (Jagiellonian University Medical College)
Wang, Chew Yin (University of Malaya)
Landoni, Giovanni (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Forget, Patrice (Universitair Ziekenhuis Brussel)
Popova, Ekaterine (Institut d'Investigació Biomèdica Sant Pau)
Wood, Gavin (Queen's University)
Nabi Nur, Aamer (Shifa International Hospital)
John, Bobby (Christian Medical College)
Ślȩczka, Pawel (SPZOZ)
Feibel, Robert J. (University of Ottawa)
Balaguer Castro, Mariano (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Deheshi, Benjamin (Sharif Surgical Oncology)
Winemaker, Mitchell (McMaster University (Canadà))
De Beer, Justin (McMaster University (Canadà))
Kolesar, Richard (McMaster University (Canadà))
Teixidor Serra, Jordi (Hospital Universitari Vall d'Hebron)
Tomas-Hernandez, Jordi (Hospital Universitari Vall d'Hebron)
McGillion, Michael (McMaster University (Canadà))
Shanthanna, Harsha (McMaster University (Canadà))
Moppett, Iain (University of Nottingham)
Vincent, Jessica (Population Health Research Institute)
Pettit, Shirley (Population Health Research Institute)
Harvey, Valerie (Population Health Research Institute)
Gauthier, Leslie (Hamilton Health Sciences)
Alvarado, Kim (McMaster University (Canadà))
Devereaux, P. J (McMaster University (Canadà))
Universitat Autònoma de Barcelona

Fecha:	2019
Resumen:	Introduction Annually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%-10% at 30 days and 10%-20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial - HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications. Methods and analysis HIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients ≥45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients. Ethics and dissemination All centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources. Trial registration number NCT02027896; Pre-results.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Accelerated surgery ; Hip fracture ; Randomised control trial
Publicado en:	BMJ open, Vol. 9 Núm. 4 (january 2019) , p. e028537, ISSN 2044-6055

DOI: 10.1136/bmjopen-2018-028537
PMID: 31048449

8 p, 533.0 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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