Drug-related deaths in a tertiary hospital : Characteristics of spontaneously reported cases and comparison to cases detected from a retrospective study
Arellano, Ana Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alcubilla, Pau (Hospital Clínic i Provincial de Barcelona)
Farré, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Montané, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Fecha:	2021
Resumen:	Drug-related deaths (DRDs) are a common cause of hospital death. Pharmacovigilance, either as spontaneous reporting or active surveillance, plays a key role in the detection and reporting of suspected adverse drug reactions (ADRs). We conducted a retrospective analysis of all DRDs spontaneously reported to a pharmacovigilance program of a tertiary hospital, by health care pro-fessionals. We compared these results to those of a previous retrospective study conducted in the same hospital from the hospital's mortality registry. From 1460 spontaneous reported ADRs in a 10-year period, 73 (5%) were DRDs. The median age of DRD was 75 years (range 1 month-94) and 60. 3% were men. The most frequent DRDs were hemorrhages (41. 1%), followed by infections (17. 8%). The most frequently involved drugs were anticoagulants and/or antithrombotic (30%), and antineoplastics (26. 3%). When comparing both studies, spontaneous reporting detected more type B reactions (p < 0. 001) and hospital-acquired DRD (p < 0. 001); the number of concomitant drugs was higher (p = 0. 0035); and the kind of ADR were different. The combination of several methods is mandatory to detect, assess, understand, and design strategies to prevent ADRs in a hospital setting, to ensure patient safety.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Journal of clinical medicine, Vol. 10 Núm. 18 (september 2021) , p. 4053, ISSN 2077-0383

DOI: 10.3390/jcm10184053
PMID: 34575164

15 p, 286.2 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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