Precision medicine in acute respiratory distress syndrome : workshop report and recommendations for future research
Bos, Lieuwe D (University of Amsterdam)
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Constantin, Jean-Michel (Sorbonne University)
Hagens, Laura A. (University of Amsterdam)
Heijnen, Nanon (University of Maastricht)
Laffey, John (University Hospital Galway)
Meyer, Nuala (University of Pennsylvania Perelman School of Medicine)
Papazian, Laurent (North hospital - Aix-Marseille University)
Pisani, Lara (Policlinico S.Orsola-Malpighi)
Schultz, Marcus J. (University of Amsterdam)
Shankar-Hari, Manu (King's College London)
Smit, Marry R. (University of Amsterdam)
Summers, Charlotte (University of Cambridge)
Ware, Lorraine B. (Vanderbilt University Medical Center)
Scala, Raffaele (S. Donato Hospital)
Calfee, Carolyn S. (University of California)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for ARDS has been disappointing, possibly due to the enormous heterogeneity within the syndrome. In this perspective from the European Respiratory Society research seminar on "Precision medicine in ARDS", we will summarise the current evidence for heterogeneity, explore the evidence in favour of precision medicine and provide a roadmap for further research in ARDS. There is evident variation in the presentation of ARDS on three distinct levels: 1) aetiological; 2) physiological and 3) biological, which leads us to the conclusion that there is no typical ARDS. The lack of a common presentation implies that intervention studies in patients with ARDS need to be phenotype aware and apply a precision medicine approach in order to avoid the lack of success in therapeutic trials that we faced in recent decades. Deeper phenotyping and integrative analysis of the sources of variation might result in identification of additional treatable traits that represent specific pathobiological mechanisms, or so-called endotypes. Acute respiratory distress syndrome (ARDS) shows variation on three distinct levels: aetiological, physiological and biological. The lack of a common presentation implies that intervention studies in patients with ARDS need to be phenotype aware and apply a precision medicine approach.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	European Respiratory Review, Vol. 30 (february 2021) , ISSN 1600-0617

DOI: 10.1183/16000617.0317-2020
PMID: 33536264

11 p, 810.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles