Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease : A Multicentre Study of Geteccu
García García, María José (Universidad de Cantabria)
Rivero, Montserrat (Universidad de Cantabria)
Miranda Bautista, José (Hospital Universitario Gregorio Marañón)
Bastón Rey, Iria (Hospital Universitario Clínico de Santiago)
Mesonero, Francisco (Hospital Universitario Ramón y Cajal)
Leo Carnerero, Eduardo (Hospital Universitario Virgen del Rocío)
Casas Deza, Diego (Hospital Universitario Miguel Servet)
Cagigas Fernandez, Carmen (Hospital Universitario Marqués de Valdecilla)
Martin Cardona, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
El Hajra, Ismael (Hospital Universitario Puerta de Hierro)
Hernández Aretxabaleta, Nerea (Hospital Universitario de Basurto)
Pérez Martínez, Isabel (Hospital Universitario Central de Asturias)
Fuentes Valenzuela, Esteban (Hospital Universitario Río Hortega)
Jiménez, Nuria (Hospital General Universitario de Elche)
Rubín de Célix, Cristina (Hospital Universitario de La Princesa)
Gutiérrez Casbas, Ana (Hospital General de Alicante)
Suárez Ferrer, Cristina (Hospital Universitario La Paz)
Huguet, José María (Hospital General Universitario de Valencia)
Fernández Clotet, Agnes (Hospital Clínic i Provincial de Barcelona)
González Vivó, María (Hospital del Mar (Barcelona, Catalunya))
Del Val, Blanca (Hospital Rafael Méndez)
Castro Poceiro, Jesús (Hospital Sant Joan Despí-Moisès Broggi)
Melcarne, Luigi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Dueñas, Carmen (Hospital Universitario de Cáceres)
Izquierdo, Marta (Hospital Universitario de Cabueñes)
Monfort, David (Gastroenterology Department, Consorci Sanitari de Terrassa)
Bouhmidi, Abdel (Hospital de Santa Bárbara)
Ramírez De la Piscina, Patricia (Hospital Universitario Vitoria-Gastéiz)
Romero, Eva (Hospital Clínic Universitari (València))
Molina, Gema (Hospital Arquitecto Marcide)
Zorrilla, Jaime (Hospital Universitario Gregorio Marañón)
Calvino Suárez, Cristina (Hospital Universitario Clínico de Santiago)
Sánchez, Eugenia (Hospital Universitario Ramón y Cajal)
Nuñez, Andrea (Hospital Universitario Virgen del Rocío)
Sierra, Olivia (Hospital Universitario Miguel Servet)
Castro, Beatriz (Universidad de Cantabria)
Zabana, Yamile (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
González Partida, Irene (Hospital Universitario Puerta de Hierro)
De la Maza, Saioa (Hospital Universitario de Basurto)
Castaño-García, Andrés (Hospital Universitario Central de Asturias)
Nájera Muñoz, Rodrigo (Hospital Universitario Río Hortega)
Sánchez Guillén, Luis (Hospital General Universitario de Elche)
Riat Castro, Micaela (Hospital Universitario de La Princesa)
Rueda, José Luis (Hospital Universitario La Paz)
Benítez, José Manuel (Hospital Reina Sofía)
Delgado Guillena, Pedro (Hospital General de Granollers)
Tardillo, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Peña, Elena (Hospital Royo Villanova)
Frago Larramona, Santiago (Complejo Hospitalario de Soria)
Rodríguez Grau, María Carmen (Hospital Universitario de Henares)
Plaza, Rocío (Hospital Universitario Infanta Leonor)
Pérez Galindo, Pablo (Complejo Hospitalario Universitario de Pontevedra)
Martínez Cadilla, Jesús (Hospital Álvaro Cunqueiro (Vigo))
Menchén, Luis (Hospital Universitario Gregorio Marañón)
Barreiro de-Acosta, Manuel (Hospital Universitario Clínico de Santiago)
Sánchez Aldehuelo, Rubén (Hospital Universitario Ramón y Cajal)
De la Cruz, María Dolores (Hospital Universitario Virgen del Rocío)
Lamuela, Luis Javier (Hospital Universitario Miguel Servet)
Marín, Ignacio (Hospital Universitario Gregorio Marañón)
Nieto García, Laura (Hospital Universitario Clínico de Santiago)
López San Román, Antonio (Hospital Universitario Ramón y Cajal)
Herrera, José Manuel (Hospital Universitario Virgen del Rocío)
Chaparro, María (Hospital Universitario de La Princesa)
P. Gisbert, Javier (Hospital Universitario de La Princesa)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1. 5; 95% CI: 1. 2-2. 0), urgent surgery (OR: 1. 6; 95% CI: 1. 2-2. 2), laparotomy approach (OR: 1. 5; 95% CI: 1. 1-1. 9) and severe anaemia (OR: 1. 8; 95% CI: 1. 3-2. 6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1. 2; 95% CI: 0. 97-1. 58), although it could be a risk factor for postoperative infections (OR 1. 5; 95% CI: 1. 03-2. 27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anti-TNF ; Crohn's disease ; Inflammatory bowel disease ; Postoperative complications ; Preoperative therapy ; Surgery ; Ulcerative colitis ; Ustekinumab ; Vedolizumab
Published in:	Journal of clinical medicine, Vol. 10 (september 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10194402
PMID: 34640421

17 p, 742.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles