Global Longitudinal Strain Predicts Outcomes in Patients with Reduced Left Ventricular Function Undergoing Transcatheter Edge-to-Edge Mitral Repair
Fernández-Peregrina, Estefanía (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Asmarats, Lluís (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Estevez-Loureiro, Rodrigo (Hospital Álvaro Cunqueiro (Vigo))
Pascual, Isaac (Hospital Universitario Central de Asturias)
Bastidas, Diana (Hospital Clínico San Carlos (Madrid))
Benito-González, Tomás (Hospital Universitario de León)
Caneiro-Queija, Berenice (Hospital Álvaro Cunqueiro (Vigo))
Avanzas, Pablo (Hospital Universitario Central de Asturias)
De Agustin, Jose Alberto (Hospital Clínico San Carlos (Madrid))
Fernández-Vázquez, Felipe (Hospital Universitario de León)
Barreiro-Pérez, Manuel (Hospital Álvaro Cunqueiro (Vigo))
Leon, Victor (Hospital Universitario Central de Asturias)
Nombela-Franco, Luís (Hospital Clínico San Carlos (Madrid))
Garrote, Carmen (Hospital Universitario de León)
Li, Chi Hion (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Baz, José Antonio (Hospital Álvaro Cunqueiro (Vigo))
Adeba, Antonio (Hospital Universitario Central de Asturias)
Sans-Roselló, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gualis, Javier (Hospital Universitario de León)
Arzamendi, Dabit (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Background: The timing and selection of optimal candidates for mitral transcatheter edge-to-edge valve repair remains to be fully determined, especially in cases with severely depressed left ventricular ejection fraction (LVEF). The objective of this study is to evaluate the prognostic value of myocardial strain (LVGLS) in this setting. Methods: Retrospectively, 172 consecutive patients with LVEF ≤40% and severe MR treated with MitraClip were included. Four groups were generated according to the LVEF (<30% or ≥ 30%) and median LVGLS. The primary end-point was cardiovascular mortality. Results: Procedural success was high (96. 5%) and complications were rare. At one-year follow-up, 82. 5% of patients maintained MR grade ≤2, 79. 2% were at a NYHA class ≤II and a reduction of 80% in heart failure admissions was observed in all groups. Interestingly, among patients with a more depressed LVEF, LVGLS was found to be an independent predictor for cardiovascular mortality (HR: 3. 3; 95% CI: 1. 1-10, p = 0. 023). Conclusions: Mitral valve repair with MitraClip is safe and it improves the mid-term functional class of patients regardless of LVEF. LVGLS can help in the selection of optimal candidates and timing for this procedure, as well as in the recognition of those patients with worse prognoses.
Note:	UDTAULI
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Left ventricular global longitudinal strain ; MitraClip ; Mitral regurgitation
Published in:	Journal of clinical medicine, Vol. 12 (june 2023) , ISSN 2077-0383

DOI: 10.3390/jcm12124116
PMID: 37373808

11 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles