Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain : Algorithm Benchmarking and Model Optimization
Ge, Ruiyang (University of British Columbia)
Yu, Yuetong (University of British Columbia, Vancouver)
Qi, Yi Xuan (University of British Columbia)
Fan, Yunan Vera (University of British Columbia)
Chen, Shiyu (University of British Columbia)
Gao, Chuntong (University of British Columbi)
Haas, Shalaila S (Icahn School of Medicine at Mount Sinai)
Modabbernia, Amirhossein (Icahn School of Medicine at Mount Sinai)
New, Faye (Icahn School of Medicine at Mount Sinai)
Agartz, Ingrid (Karolinska Institutet & Stockholm Health Care Services)
Asherson, Philip (King's College London)
Ayesa-Arriola, Rosa (Instituto de Investigación Marqués de Valdecilla)
Banaj, Nerisa (IRCCS Santa Lucia Foundation)
Banaschewski, Tobias (Central Institute of Mental Health)
Baumeister, Sarah (Central Institute of Mental Health)
Bertolino, Alessandro (University of Bari Aldo Moro)
Boomsma, Dorret I. (Vrije Universiteit Amsterdam)
Borgwardt, Stefan (University of Lübeck)
Bourque, Josiane (University of Pennsylvania)
Brandeis, Daniel (University of Zürich, Zurich)
Breier, Alan (Indiana University School of Medicine)
Brodaty, Henry (University of New South Wales)
Brouwer, Rachel M (Vrije Universiteit Amsterdam)
Buckner, Randy (Harvard Medical School)
Buitelaar, Jan (Radboud University Medical Center)
Cannon, Dara M (National University of Ireland Galway)
Caseras, Xavier (MRC Centre for Neuropsychiatric Genetics and Genomics)
Cervenka, Simon (Uppsala University)
Conrod, Patricia (Université de Montréal)
Crespo-Facorro, Benedicto (Mental Health Research Networking Center (CIBERSAM))
Crivello, Fabrice (Université de Bordeaux)
Crone, Eveline A (Leiden University, Leiden)
de Haan, Liewe (Amsterdam UMC)
de Zubicaray, Greig (Queensland University of Technology)
Di Giorgio, Annabella (Fondazione IRCCS Casa Sollievo della Sofferenza)
Erk, Susanne (Charité - Universitätsmedizin Berlin)
Fisher, Simon E (Radboud University Medical Center)
Franke, Barbara (Donders Institute for Brain, Cognition and Behaviour (The Netherlands))
Frodl, Thomas (RWTH Aachen University)
Glahn, David C. (Boston Children's Hospital (Boston, Estats Units d'Amèrica))
Grotegerd, Dominik (University of Muenster)
Gruber, Oliver (Heidelberg University)
Gruner, Patricia (Yale University)
Gur, Raquel E (University of Pennsylvania)
Gur, Ruben C (University of Pennsylvania, PhiladelphiaA)
Harrison, Ben J (The University of Melbourne & Melbourne Health)
Hatton, Sean N. (University of California San Diego)
Hickie, Ian (Brain and Mind Centre, University of Sydney)
Howells, Fleur M. (University of Cape Town)
Pol, Hilleke E Hulshoff (Utrecht University)
Huyser, Chaim (Amsterdam UMC Department of Child and Adolescent Psychiatry)
Jernigan, Terry L (University of California)
Jiang, Jiyang (University of New South Wales)
Joska, John A (University of Cape Town)
Kahn, René S (Icahn School of Medicine at Mount Sinai)
Kalnin, Andrew J (The Ohio State University College of Medicine)
Kochan, Nicole A (University of New South Wales)
Koops, Sanne (University Medical Center Utrecht)
Kuntsi, Jonna (King's College London)
Lagopoulos, Jim (University of the Sunshine Coast)
Lazaro, Luisa (Hospital Clínic Barcelona)
Lebedeva, Irina (Mental Health Research Center (Moscou, Rússia))
Lochner, Christine (Stellenbosch University)
Martin, Nicholas G. (QIMR Berghofer Medical Research Institute)
Mazoyer, Bernard (Université de Bordeaux)
McDonald, Brenna C (Indiana University School of Medicine)
McDonald, Colm (National University of Ireland Galway)
McMahon, Katie L (Queensland University of Technology)
Nakao, Tomohiro (Kyushu University)
Nyberg, Lars (Umeå University)
Piras, Fabrizio (IRCCS Santa Lucia Foundation)
Portella Moll, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau)
Qiu, Jiang (Beijing Normal University)
Roffman, Joshua L (Harvard Medical School)
Sachdev, Perminder S. (University of New South Wales)
Sanford, Nicole (University of British Columbia)
Satterthwaite, Theodore D (University of Pennsylvania)
Saykin, Andrew J (Indiana University School of Medicine)
Schumann, Gunter (King's College London)
Sellgren, Carl M (Karolinska Institute)
Sim, Kang (Institute of Mental Health)
Smoller, Jordan W (Massachusetts General Hospital)
Soares, Jair (University of Texas Health Harris County Psychiatric Center)
Sommer, Iris E (University Medical Center Groningen)
Spalletta, Gianfranco (IRCCS Santa Lucia Foundation)
Stein, Dan J (University of Cape Town (South Africa))
Tamnes, Christian K. (University of Oslo)
Thomopolous, Sophia I (Keck USC School of Medicine)
Tomyshev, Alexander S (Mental Health Research Center (Moscou, Rússia))
Tordesillas-Gutiérrez, Diana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Trollor, Julian (University of New South Wales)
van 't Ent, Dennis (Vrije Universiteit Amsterdam)
van den Heuvel, Odile A (Vrije Universiteit Amsterdam)
van Erp, Theo GM (University of California)
van Haren, Neeltje EM (Erasmus University Medical Centre)
Vecchio, Daniela (IRCCS Santa Lucia Foundation)
Veltman, Dick J (Vrije Universiteit Amsterdam)
Walter, Henrik (Charité - Universitätsmedizin Berlin)
Wang, Yang (Medical College of Wisconsin)
Weber, Bernd (University of Bonn Germany)
Wei, Dongtao (Southwest University)
Wen, Wei (University of New South Wales)
Westlye, Lars T (University of Oslo)
Wierenga, Lara M (Leiden University)
Williams, Steven CR (King's College London)
Wright, Margaret J (University of Queensland)
Medland, Sarah (University of Queensland)
Wu, Mon-Ju (University of Texas Health Science Center)
Yu, Kevin (University of British Columbia)
Jahanshad, Neda (Keck USC School of Medicine)
Thompson, Paul M (Keck USC School of Medicine)
Frangou, Sophia (Icahn School of Medicine at Mount Sinai)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The Multivariate Factorial Polynomial Regression (MFPR) emerged as the preferred algorithm optimized using nonlinear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins, and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3,000 study participants. The model and scripts described here are freely available through CentileBrain ().
Ayudas:	European Commission. Horizon 2020 667302 European Commission. Horizon 2020 643051 European Research Council ERC- 230374 Ministerio de Economía y Competitividad PI14/00918 Ministerio de Economía y Competitividad PI14/00639
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	bioRxiv, december 2023

DOI: 10.1101/2023.01.30.523509
PMID: 38076938

34 p, 1.4 MB

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