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16 p, 2.3 MB Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis / Julià Cano, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gómez, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; López-Lasanta, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Blanco-García, F.J (Complejo Hospitalario Universitario de A Coruña) ; Erra, Alba (Hospital de San Rafael (Madrid). Servicio de Reumatología) ; Fernández-Nebro, Antonio (Hospital Regional Universitario de Málaga) ; Mas, Antonio Juan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ; Pérez-García, Carolina (Hospital del Mar (Barcelona, Catalunya)) ; García Vivar, Ma Luz (Hospital Universitario Basurto. Servicio de Reumatología) ; Sánchez-Fernández, Simón (Hospital General La Mancha Centro. Servicio de Reumatología) ; Alperi-López, Mercedes (Hospital Universitario Central de Asturias) ; Sanmartí, Raimon (Fundació Clínic. Servei de Reumatologia) ; Ortiz, Ana María (Hospital Universitario de La Princesa. Servicio de Reumatología) ; Fernandez-Cid, Carlos Marras (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ; Díaz Torne, César (Institut d'Investigació Biomèdica Sant Pau) ; Moreno Ruzafa, Estefanía (Consorci Sanitari de l'Alt Penedès. Unitat de Reumatologia) ; Li, Tianlu (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Mateu, Sergio H. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Absher, Devin M. (HudsonAlpha Institute for Biotechnology) ; Myers, Richard M. (HudsonAlpha Institute for Biotechnology) ; Tornero Molina, Jesús (Hospital Universitario de Guadalajara. Servicio de Reumatología) ; Marsal, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhibitor (TNFi) therapy. [...]
2022 - 10.1016/j.ebiom.2022.104053
EBioMedicine, Vol. 80 (june 2022) , p. 104053  
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2.
13 p, 3.0 MB Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q / Ademà, Vera (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Walter, Wencke (Munich Leukemia Laboratory) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hutter, Stephan (Munich Leukemia Laboratory) ; La Framboise, Thomas (Department of Genetics and Genome Sciences. Case Western Reserve University) ; Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ; Meggendorfer, Manja (Munich Leukemia Laboratory) ; Radivoyevitch, Tomas (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pellagatti, Andrea (Blood Cancer UK Molecular Haematology Unit. Nuffield Division of Clinical Laboratory Sciences. Radcliffe Department of Medicine. University of Oxford and Oxford BRC Haematology Theme) ; Haferlach, Claudia (Munich Leukemia Laboratory) ; Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine) ; Kern, Wolfgang (Munich Leukemia Laboratory) ; Visconte, Valeria (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Sekeres, Mikkael (Leukemia Program. Department of Hematology and Medical Oncology. Cleveland Clinic. Cleveland Clinic Taussig Cancer Institute) ; Barnard, John (Department of Quantitative Health Sciences. Cleveland Clinic. Lerner Research Institute) ; Haferlach, Torsten (Munich Leukemia Laboratory) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Maciejewski, Jaroslaw (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute)
Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. [...]
2022 - 10.1016/j.ebiom.2022.104059
EBioMedicine, Vol. 80 (june 2022) , art. 104059  
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