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11 p, 814.5 KB |
Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals : Examining the Necessity to Adjust for Biomarker Status in Normative Data
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Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Maastricht University) ;
Jansen, Willemijn J. (Maastricht University) ;
Vandenberghe, Rik (KU Leuven) ;
Gabel, Silvy (KU Leuven) ;
Estanga, Ainara (CITA-Alzheimer Foundation) ;
Ecay-Torres, Mirian (CITA-Alzheimer Foundation) ;
Tomassen, Jori (Vrije Universiteit Amsterdam) ;
den Braber, Anouk (Vrije Universiteit Amsterdam) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Wallin, Anders (University of Gothenburg Sahlgrenska Academy) ;
Kettunen, Petronella (University of Oxford) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Rami, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Chetelat, Gaël (Université de Caen-Normandie GIP Cyceron) ;
de la Sayette, Vincent (CHU de Caen) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Freund-Levi, Yvonne (Norrtälje Hospital Tiohundra) ;
Johannsen, Peter (University of Copenhagen) ;
Novak, Gerald P. (Janssen Pharmaceutical Research and Development) ;
Ramakers, Inez (Maastricht University) ;
Verhey, Frans R. (Maastricht University) ;
Visser, Pieter J. (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. [...]
2018 -  10.3389/fnagi.2018.00193
Frontiers in aging neuroscience, Vol. 10 (25 2018) , p. 193
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6 p, 731.5 KB |
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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Stamate, Daniel (University of London) ;
Kim, Min (Steno Diabetes Center Copenhagen) ;
Proitsi, Petroula (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (King's College London) ;
Bos, Isabelle (Amsterdam UMC) ;
Vos, Stephanie J.B. (Maastricht University) ;
Vandenberghe, Rik (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Bordet, Régis (University of Lille) ;
Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (University of Antwerp) ;
Visser, Pieter J. (Amsterdam UMC) ;
Lovestone, Simon (Janssen-Cilag UK Ltd) ;
Legido-Quigley, Cristina (King's College London) ;
Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 - 10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938
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3.
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11 p, 783.1 KB |
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
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Shi, Liu (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Winchester, Laura (University of Oxford) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Hong, Shengjun (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J. (South London and Maudsley NHS Foundation) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Amsterdam UMC. University Medical Center) ;
Buckley, Noel J (University of Oxford) ;
Kate, Mara ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (VUB University Hospital Brussels (UZ Brussel)) ;
De Roeck, Ellen E. (Institute Born-Bunge. University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter Copenhagen University Hospital ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Baker, Susan (Janssen R&D) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R&D. LLC) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Lovestone, Simon (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Universitat Autònoma de Barcelona
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. [...]
2019 - 10.1016/j.jalz.2019.06.4951
Alzheimer's & Dementia, Vol. 15 Núm. 11 (november 2019) , p. 1478-1488
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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13 p, 162.5 KB |
Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort
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Westwood, Sarah (University of Oxford) ;
Baird, Alison L (University of Oxford) ;
Anand, Sneha N. (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Kormilitzin, Andrey (University of Oxford) ;
Shi, Liu (University of Oxford) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Maastricht University) ;
Baker, Susan (Janssen R and D) ;
Buckley, Noel J (University of Oxford) ;
Ten Kate, Mara (Vrije Universiteit University Medical Center) ;
Scheltens, Philip (Vrije Universiteit University Medical Center) ;
Teunissen, Charlotte E. (Vrije Universiteit University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Ku Leuven) ;
Meersmans, Karen (Ku Leuven) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
De Roeck, Ellen E. (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (Irccs Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R and D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Geneva University Hospitals) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Bertram, Lars (University of Oslo) ;
Barkhof, Frederik (Ucl Institutes of Neurology and Healthcare Engineering) ;
Zetterberg, Henrik (Ucl Institute of Neurology) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R and D. Llc) ;
Visser, Pieter Jelle (Vu University Medical Center) ;
Lovestone, Simon (Janssen R and D) ;
Universitat Autònoma de Barcelona
We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. [...]
2020 - 10.3233/JAD-190434
Journal of Alzheimer's disease, Vol. 74 Núm. 1 (2020) , p. 213-225
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2 p, 685.2 KB |
Correction : Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease
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Visser, Pieter Jelle (Karolinska Institutet) ;
Reus, Lianne M. (Vrije Universiteit Amsterdam) ;
Gobom, Johan (Sahlgrenska Academy at the University of Gothenburg) ;
Jansen, Iris E (VU University) ;
Dicks, Ellen (Vrije Universiteit Amsterdam) ;
van der Lee, Sven J. (Vrije Universiteit Amsterdam) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans R. J. (Maastricht University) ;
Popp, Julius (University Hospital Zurich (Suïssa)) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Vandenberghe, Rik (KU Leuven) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel) ;
Freund-Levi, Yvonne (Örebro University) ;
Froelich, Lutz (University of Heidelberg) ;
Sleegers, Kristel (University of Antwerp) ;
Dobricic, Valerija (University of Lübeck) ;
Lovestone, Simon (Jansen UK, High Wycombe, UK) ;
Streffer, Johannes (AC Immune SA) ;
Vos, Stephanie J. B. (Maastricht University) ;
Bos, Isabelle (Maastricht University) ;
Smit, August B. (Vrije Universiteit Amsterdam) ;
Blennow, Kaj (Sahlgrenska Academy at the University of Gothenburg) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Bertram, Lars (University of Oslo) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Tijms, Betty M. (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
2022 - 10.1186/s13024-022-00540-0
Molecular neurodegeneration, Vol. 17 (may 2022)
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14 p, 1.6 MB |
Characteristics of subjective cognitive decline associated with amyloid positivity
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Janssen, Olin (Maastricht University. School for Mental Health and Neuroscience) ;
Jansen, W.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Vos, S.J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Parnetti, Lucilla (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Gabryelewicz, T. (Department of Neurodegenerative Disorders. Mossakowski Medical Research Centre. Polish Academy of Sciences) ;
Fladby, T. (Department of Neurology. Akershus University Hospital) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villeneuve, S. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Hort, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Epelbaum, S. (Inserm Sorbonne Université. Inria. Aramis project-team. Paris Brain Institute - Institut du Cerveau (ICM)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel. (VUB) Brussels. and University of Antwerp) ;
van der Flier, W.M. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Landau, S. (Helen Wills Neuroscience Institute. University of California) ;
Popp, J. (Old Age Psychiatry. University Hospital of Lausanne) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Scheltens, P. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Rikkert, M.O. (Department of Geriatric Medicine. Radboud Alzheimer Center. Radboud University Medical Center) ;
Snyder, P.J. (Kingston. The University of Rhode Island) ;
Rowe, C. (Department of Molecular Imaging & Therapy. Austin Health) ;
Chételat, G.. (Institut National de la Santé et de la Recherche Médicale (Inserm)) ;
Ruíz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chipi, E. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Wolfsgruber, S. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Heneka, M. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Boecker, H. (Functional Neuroimaging Group. Department of Radiology. University Hospital Bonn) ;
Peters, O. (Charité - Universitätsmedizin Berlin) ;
Jarholm, J. (Department of Neurology. Akershus University Hospital) ;
Rami, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tort-Merino, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Binette, A.P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Poirier, J. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Rosa-Neto, P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Cerman, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Dubois, B. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Teichmann, M. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau) ;
Ebenau, J. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Pocnet, C. (Old Age Psychiatry. University Hospital of Lausanne) ;
Eckerström, M. (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Thompson, L. (Kingston. The University of Rhode Island) ;
Villemagne, V. (Department of Psychiatry. University of Pittsburgh) ;
Buckley, R. (righam and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Burnham, S. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Delarue, M. (Institut National de la Sant. et de la Recherche M.dicale (Inserm)) ;
Freund-Levi, Yvonne (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet) ;
Wallin, Å.K. (Department of Clinical Sciences Malmö. Clinical Memory Research Unit. Lund University) ;
Ramakers, I. (Maastricht University. School for Mental Health and Neuroscience) ;
Tsolaki, Magda (Memory and Dementia Center. 3rd Department of Neurology. "G Papanicolau. " General Hospital. Aristotle University of Thessaloniki) ;
Soininen, H. (Institute of Clinical Medicine. Neurology. University of Eastern Finland) ;
Hampel, H. (GRC no 21. Alzheimer Precision Medicine (AMP). AP-HP. Pitié-Salpêtrière Hospital. Sorbonne University) ;
Spiru, L. (Geriatrics- Gerontology and Old Age Psychiatry. Alzheimer Unit. Ana Aslan International Foundation - Memory Center and Longevity Medicine) ;
Tijms, B. (Maastricht University. School for Mental Health and Neuroscience) ;
Ossenkoppele, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Verhey, F.R.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Jessen, F. (German Center For Neurodegenerative Diseases/Clinical Research. Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE). Zentrum für klinische Forschung/AG) ;
Visser, P.J. (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet)
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. [...]
2022 - 10.1002/alz.12512
Alzheimer's & Dementia, Vol. 18 Núm. 10 (october 2022) , p. 1832-1845
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13 p, 1.8 MB |
Replication study of plasma proteins relating to Alzheimer's pathology
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Shi, Liu (University of Oxford. Department of Psychiatry) ;
Winchester, Laura M. (University of Oxford. Department of Psychiatry) ;
Westwood, Sarah (University of Oxford. Department of Psychiatry) ;
Baird, Alison L (University of Oxford. Department of Psychiatry) ;
Anand, Sneha N (University of Oxford. Department of Psychiatry) ;
Buckley, Noel J. (University of Oxford. Department of Psychiatry) ;
Hye, Abdul (Maurice Wohl Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Bos, Isabelle (Alzheimer Center. VU University Medical Center) ;
Vos, Stephanie J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (KU Leuven. Laboratory for Cognitive Neurology) ;
Meersmans, Karen (KU Leuven. Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel and Center for Neurociences (C4N). Vrije Universiteit Brussel) ;
De Roeck, Ellen E (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (AIX marseille university. INS. Ap-hm) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
Bordet, Régis (Inserm. University of Lille. CHU Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University. School for Mental Health and Neuroscience) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet. Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet Center for Alzheimer Research. Division of Clinical Geriatrics. School of Medical Sciences Örebro University and Department of Neurobiology. Caring Sciences and Society (NVS)) ;
Frölich, Lutz (Department of Geriatric Psychiatry. Zentralinstitut für Seelische Gesundheit. University of Heidelberg) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. Institutes of Neurogenetics and Cardiogenetics. University of Lübeck) ;
Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Andreasson, Ulf (Clinical Sahlgrenska University Hospital) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (UCB. Braine-l'Alleud. Belgium. formerly Janssen R&D. LLC Beerse) ;
Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College) ;
Bertram, Lars (Department of Psychology. University of Oslo) ;
Visser, Pieter Jelle (Alzheimer Center. VU University Medical Center) ;
Kolb, Hartmuth C. (Janssen R&D) ;
Narayan, Vaibhav A. (Janssen R&D) ;
Lovestone, Simon (Janssen R&D) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Introduction: This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis. [...]
2021 - 10.1002/alz.12322
Alzheimer's & Dementia, Vol. 17 Núm. 9 (september 2021) , p. 1452-1464
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15 p, 2.1 MB |
Sex-specific metabolic pathways were associated with alzheimer's disease (Ad) endophenotypes in the european medical information framework for ad multimodal biomarker discovery cohort
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Xu, J. (King's College London) ;
Green, R. (King's College London) ;
Kim, M. (Steno Diabetes Center) ;
Lord, J. (King's College London) ;
Ebshiana, A. (King's College London) ;
Westwood, S. (Department of Psychiatry. University of Oxford) ;
Baird, Alison L (Department of Psychiatry. University of Oxford) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford) ;
Shi, L. (Department of Psychiatry. University of Oxford) ;
Hye, Abdul (King's College London) ;
Snowden, S. G. (King's College London) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, S. J. B. (Maastricht University) ;
Vandenberghe, Rik (Alzheimer Center. VU University Medical Center) ;
Teunissen, C. E. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Kate, M. T. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Scheltens, P. (Alzheimer Center. VU University Medical Center) ;
Gabel, Silvy (University Hospitals Leuven (Bèlgica)) ;
Meersmans, K. (University Hospitals Leuven (Bèlgica)) ;
Blin, Olivier (Clinical Pharmacology & Pharmacovigilance Department. Aix-Marseille University-CNRS) ;
Richardson, J. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
De Roeck, Ellen E (University of Antwerp. Institute Born-Bunge) ;
Engelborghs, Sebastiaan (RUniversity of Antwerp. Institute Born-Bunge) ;
Sleegers, Kristel (Complex Genetics of Alzheimer's Disease Group. VIB Center for Molecular Neurology. VIB) ;
Bordet, Régis (Université de Lille. Department of Medical Pharmacology) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kettunen, Petronella (University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, F. R. J. (Maastricht University. Alzheimer Centrum Limburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundación CITA-Alzhéimer Fundazioa) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, L. (University of Heidelberg. Department of Geriatric Psychiatry) ;
Dobricic, Valerija (University of Lübeck. Institutes of Neurogenetics and Cardiogenetics) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Wallin, Anders (University of Gothenburg. Sahlgrenska Academy) ;
Popp, J. (University Hospital of Psychiatry Zürich) ;
Martinez-Lage, P. (Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Oslo. Department of Psychology) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, J. (Reference Center for Biological Markers of Dementia (BIODEM). Institute Born-Bunge. University of Antwerp) ;
Jelle Visser, P. (Maastricht University. Alzheimer Centrum Limburg) ;
Lovestone, Simon (Janssen-Cilag UK Ltd.) ;
Proitsi, P. (King's College London) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Universitat Autònoma de Barcelona
Background: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. [...]
2021 - 10.3390/biomedicines9111610
Biomedicines, Vol. 9 Núm. 11 (november 2021) , p. 1610
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10.
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16 p, 2.1 MB |
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease
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Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Reus, Lianne M. (Vrije Universiteit Amsterdam) ;
Gobom, Johan (Sahlgrenska Academy at the University of Gothenburg) ;
Jansen, Iris E (VU University) ;
Dicks, Ellen (Vrije Universiteit Amsterdam) ;
van der Lee, Sven J. (Vrije Universiteit Amsterdam) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans R. J. (Maastricht University) ;
Popp, Julius (University Hospital Zurich (Suïssa)) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Vandenberghe, Rik (KU Leuven) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel) ;
Freund-Levi, Yvonne (Örebro University) ;
Froelich, Lutz (University of Heidelberg) ;
Sleegers, Kristel (University of Antwerp) ;
Dobricic, Valerija (University of Lübeck) ;
Lovestone, Simon (High Wycombe, UK) ;
Streffer, Johannes (AC Immune SA) ;
Vos, Stephanie J. B. (Maastricht University) ;
Bos, Isabelle (Maastricht University) ;
Smit, August B. (Vrije Universiteit Amsterdam) ;
Blennow, Kaj (Sahlgrenska Academy at the University of Gothenburg) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Bertram, Lars (University of Oslo) ;
Zetterberg, Henrik (Dementia Research Institute at UCL) ;
Tijms, Betty M. (Vrije Universiteit Amsterdam) ;
Universitat Autònoma de Barcelona
Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very early disease stages, when neurodegeneration is limited, and can be normal in advanced disease stages. [...]
2022 - 10.1186/s13024-022-00521-3
Molecular neurodegeneration, Vol. 17 (march 2022)
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