Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
Kim, Min (Steno Diabetes Center Copenhagen)
Snowden, Stuart (University of Cambridge)
Suvitaival, Tommi (Steno Diabetes Center Copenhagen)
Ali, Ashfaq (Steno Diabetes Center Copenhagen)
Merkler, David J. (University of South Florida)
Ahmad, Tahmina (King's College London)
Westwood, Sarah (University of Oxford)
Baird, Alison (University of Oxford)
Proitsi, Petroula (King's College London)
Nevado-Holgado, Alejo (University of Oxford)
Hye, Abdul (Steno Diabetes Center Copenhagen)
Bos, Isabelle (Maastricht University)
Vos, Stephanie (Maastricht University)
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica))
Teunissen, Charlotte (Amsterdam Neuroscience)
ten Kate, Mara (Amsterdam Neuroscience)
Scheltens, Philip (Amsterdam UMC. University Medical Center)
Gabel, Silvy (KU Leuven)
Meersmans, Karen (KU Leuven)
Blin, Olivier
Richardson, Jill (GlaxoSmithKline R&D)
De Roeck, Ellen (University of Antwerp)
Sleegers, Kristel (VIB)
Bordet, Régis (University of Lille)
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona)
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit))
Tsolaki, Magda (AHEPA University Hospital (Grècia))
Verhey, Frans (Maastricht University)
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Peyratout, Gwendoline (Lausanne University Hospital)
Tainta, Mikel (CITA-Alzheimer Foundation)
Johannsen, Peter (Copenhagen University Hospital)
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia))
Frölich, Lutz (University of Heidelberg)
Dobricic, Valerija (University of Lübeck)
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica))
Frisoni, Giovanni B. (University of Geneva)
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona)
Wallin, Anders (University of Gothenburg)
Popp, Julius (Geneva University Hospitals)
Martinez-Lage, Pablo (CITA-Alzheimer Foundation)
Bertram, Lars (University of Lübeck)
Barkhof, Frederik (Amsterdam Neuroscience)
Ashton, Nicholas J (University of Gothenburg)
Blennow, Kaj (Sahlgrenska University Hospital (Suècia))
Zetterberg, Henrik (UK Dementia Research Institute)
Streffer, Johannes (Janssen Pharmaceutical Companies)
Visser, Pieter J. (Amsterdam Neuroscience)
Lovestone, Simon (University of Oxford)
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen)
Universitat Autònoma de Barcelona

Fecha:	2019
Resumen:	A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alzheimer's disease ; Amyloid ; Biomarkers ; Brain volume measurements ; CSF ; Cognitive function measurements ; Dementia ; EMIF-AD ; Metabolomics ; Tau
Publicado en:	Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827, ISSN 1552-5279

DOI: 10.1016/j.jalz.2019.03.004
PMID: 31078433

22 p, 986.7 KB

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