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6 p, 731.5 KB |
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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Stamate, Daniel (University of London) ;
Kim, Min (Steno Diabetes Center Copenhagen) ;
Proitsi, Petroula (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (King's College London) ;
Bos, Isabelle (Amsterdam UMC) ;
Vos, Stephanie J.B. (Maastricht University) ;
Vandenberghe, Rik (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Bordet, Régis (University of Lille) ;
Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (University of Antwerp) ;
Visser, Pieter J. (Amsterdam UMC) ;
Lovestone, Simon (Janssen-Cilag UK Ltd) ;
Legido-Quigley, Cristina (King's College London) ;
Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 -  10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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17 p, 1.4 MB |
Identification of RipAZ1 as an avirulence determinant of Ralstonia solanacearum in Solanum americanum
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Moon, Hayoung (Pohang University of Science and Technology. Department of Life Sciences) ;
Pandey, Ankita (Pohang University of Science and Technology. Department of Life Sciences) ;
Yoon, Hayeon (Pohang University of Science and Technology. Department of Life Sciences) ;
Choi, Sera (Pohang University of Science and Technology. Department of Life Sciences) ;
Jeon, Hyelim (Seoul National University. Department of Agriculture, Forestry and Bioresources) ;
Prokchorchik, Maxim (Pohang University of Science and Technology. Department of Life Sciences) ;
Jung, Gayoung (Pohang University of Science and Technology. Department of Life Sciences) ;
Witek, Kamil (University of East Anglia. The Sainsbury Laboratory) ;
Valls, Marc (Centre de Recerca en Agrigenòmica) ;
McCann, Honour C. (Max Planck Institute for Developmental Biology) ;
Kim, Min-Sung (Pohang University of Science and Technology. Department of Life Sciences) ;
Jones, Jonathan D. G. (University of East Anglia. The Sainsbury Laboratory) ;
Segonzac, Cécile (Seoul National University. Agricultural Life Science Research Institute) ;
Sohn, Kee Hoon (Pohang University of Science and Technology. School of Interdisciplinary Bioscience and Bioengineering)
Ralstonia solanacearum causes bacterial wilt disease in many plant species. Type III-secreted effectors (T3Es) play crucial roles in bacterial pathogenesis. However, some T3Es are recognized by corresponding disease resistance proteins and activate plant immunity. [...]
2021 - 10.1111/mpp.13030
Molecular plant pathology, Vol. 22, Issue 3 (March 2021) , p. 317-333
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214 p, 55.9 MB |
Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems
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Ferrari, Andrea C. (University of Cambridge) ;
Bonaccorso, Francesco (Istituto Italiano di Tecnologia) ;
Fal'ko, Vladimir (Lancaster University. Department of Physics) ;
Novoselov, Konstantin S. (University of Manchester) ;
Roche, Stephan (Institut Català de Nanociència i Nanotecnologia) ;
Bøggild, Peter (Technical University of Denmark) ;
Borini, Stefano (Nokia Technologies) ;
Koppens, Frank (Institut de Ciències Fotòniques) ;
Palermo, Vincenzo (CNR-Istituto per la Sintesi Organica e la Fotoreattività) ;
Pugno, Nicola (Queen Mary University of London) ;
Garrido, Jose (Technische Universität München) ;
Sordan, Roman (Politecnico di Milano) ;
Bianco, Alberto (Institut de Biologie Moleculaire et Cellulaire) ;
Ballerini, Laura (Università di Trieste) ;
Prato, Maurizio (Università di Trieste. Dipartimento di Scienze Farmaceutiche) ;
Lidorikis, Elefterios (University of Ioannina. Department of Materials Science and Engineering) ;
Kivioja, Jani (Nokia Technologies) ;
Marinelli, Claudio (Wilton Centre) ;
Ryhänen, Tapani (Nokia Technologies) ;
Morpurgo, Alberto (Université de Genève. Département de Physique de la Matière Condensée) ;
Coleman, Jonathan N. (Trinity College) ;
Nicolosi, Valeria (Trinity College) ;
Colombo, Luigi (Texas Instruments Incorporated) ;
Fert, Albert (Université de Paris-Sud) ;
Garcia-Hernandez, Mar (Instituto de Ciencia de Materiales de Madrid) ;
Bachtold, Adrian (Institut de Ciències Fotòniques) ;
Schneider, Gregory F. (Leiden University) ;
Guinea, Francisco (Instituto de Ciencia de Materiales de Madrid) ;
Dekker, Cees (Delft University of Technology) ;
Barbone, Matteo (University of Cambridge) ;
Sun, Zhipei (University of Cambridge) ;
Galiotis, Costas (University of Patras. Department of Chemical Engineering) ;
Grigorenko, Alexander N. (University of Manchester) ;
Konstantatos, Gerasimos (Institut de Ciències Fotòniques) ;
Kis, Andras (Ecole Polytechique Fédérale de Lausanne) ;
Katsnelson, Mikhail (Radboud University Nijmegen) ;
Vandersypen, Lieven (Delft University of Technology) ;
Loiseau, Annick (Laboratoire d'Etude des Microstructures) ;
Morandi, Vittorio (CNR-Istituto per la Microelettronica e i Microsistemi) ;
Neumaier, Daniel (Advanced Microelectronic Centre Aachen) ;
Treossi, Emanuele (CNR-Istituto per la Sintesi Organica e la Fotoreattività) ;
Pellegrini, Vittorio (Scuola Normale Superiore (Pisa, Itàlia)) ;
Polini, Marco (Scuola Normale Superiore (Pisa, Itàlia)) ;
Tredicucci, Alessandro (Scuola Normale Superiore (Pisa, Itàlia)) ;
Williams, Gareth M. (Airbus UK Ltd) ;
Hee Hong, Byung (Seoul National University. Department of Chemistry) ;
Ahn, Jong-Hyun (Yonsei University) ;
Kim, Jong Min (University of Oxford. Department of Engineering Science) ;
Zirath, Herbert (Chalmers University of Technology. Department of Microtechnology and Nanoscience) ;
Van Wees, Bart J. (University of Groningen) ;
Van Der Zant, Herre S. J. (Delft University of Technology) ;
Occhipinti, Luigi (STMicroelectronics) ;
Di Matteo, Andrea (STMicroelectronics) ;
Kinloch, Ian A. (University of Manchester) ;
Seyller, Thomas (Technische Universität Chemnitz) ;
Quesnel, Etienne (Institut LITEN) ;
Feng, Xinliang (Max-Planck-Institut für Polymerforschung) ;
Teo, Ken (Aixtron Ltd.) ;
Rupesinghe, Nalin (Aixtron Ltd.) ;
Hakonen, Pertti (Aalto University) ;
Neil, Simon R. T. (CambridgeIP) ;
Tannock, Quentin (CambridgeIP) ;
Löfwander, Tomas (Chalmers University of Technology. Department of Microtechnology and Nanoscience) ;
Kinaret, Jari (Chalmers University of Technology. Department of Applied Physics)
We present the science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching into most areas of society. [...]
2015 - 10.1039/c4nr01600a
Nanoscale, Vol. 7, Issue 11 (March 2015) , p. 4598-4810
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