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33 p, 892.7 KB |
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
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Mullins, Niamh ;
Kang, JooEun ;
Campos, Adrian I. ;
Coleman, Jonathan R.I. ;
Edwards, Alexis C. ;
Galfalvy, Hanga ;
Levey, Daniel F. ;
Lori, Adriana ;
Shabalin, Andrey ;
Starnawska, Anna ;
Su, Mei-Hsin ;
Watson, Hunna J. ;
Adams, Mark ;
Awasthi, Swapnil ;
Gandal, Michael ;
Hafferty, Jonathan D. ;
Hishimoto, Akitoyo ;
Kim, Minsoo ;
Okazaki, Satoshi ;
Otsuka, Ikuo ;
Ripke, Stephan ;
Ware, Erin B. ;
Bergen, Andrew W. ;
Berrettini, Wade H. ;
Bohus, Martin ;
Brandt, Harry ;
Chang, Xiao ;
Chen, Wei J. ;
Chen, Hsi-Chung ;
Crawford, Steven ;
Crow, Scott ;
DiBlasi, Emily ;
Duriez, Philibert ;
Fernández-Aranda, Fernando (Hospital Universitari de Bellvitge) ;
Fichter, Manfred M. ;
Gallinger, Steven ;
Glatt, Stephen J. ;
Gorwood, Philip ;
Guo, Yiran ;
Hakonarson, Hakon ;
Halmi, Katherine A. ;
Hwu, Hai-Gwo ;
Jain, Sonia ;
Jamain, Stéphane ;
Jiménez-Murcia, Susana (Hospital Universitari de Bellvitge) ;
Johnson, Craig ;
Kaplan, Allan S. ;
Kaye, Walter H. ;
Keel, Pamela K. ;
Kennedy, James L. ;
Klump, Kelly L. ;
Li, Dong (Children's Hospital of Philadelphia (Pennsilvània)) ;
Liao, Shih-Cheng ;
Lieb, Klaus ;
Lilenfeld, Lisa ;
Liu, Chih-Min ;
Magistretti, Pierre J. ;
Marshall, Christian R. ;
Mitchell, James E. ;
Monson, Eric T. ;
Myers, Richard M. ;
Pinto, Dalila ;
Powers, Abigail ;
Ramoz, Nicolas ;
Roepke, Stefan ;
Rozanov, Vsevolod ;
Scherer, Stephen W. ;
Schmahl, Christian ;
Sokolowski, Marcus ;
Strober, Michael ;
Thornton, Laura M. ;
Treasure, Janet ;
Tsuang, Ming T. ;
Witt, Stephanie H. ;
Woodside, D. Blake ;
Yilmaz, Zeynep ;
Zillich, Lea ;
Adolfsson, Rolf ;
Agartz, Ingrid ;
Air, Tracy M. ;
Alda, Martin ;
Alfredsson, Lars ;
Andreassen, Ole A. ;
Anjorin, Adebayo ;
Appadurai, Vivek ;
Soler Artigas, María (Hospital Universitari Vall d'Hebron) ;
Van der Auwera, Sandra ;
Azevedo, M. Helena ;
Bass, Nicholas ;
Bau, Claiton Henrique Dotto ;
Baune, Bernhard T. ;
Bellivier, Frank ;
Berger, Klaus ;
Biernacka, Joanna M. ;
Bigdeli, Tim B. ;
Binder, Elisabeth B. ;
Boehnke, Michael ;
Boks, Marco P. ;
Bosch, Rosa (Hospital Universitari Vall d'Hebron) ;
Braff, David L. ;
Bryant, Richard ;
Budde, Monika ;
Byrne, Enda M. ;
Cahn, Wiepke ;
Casas Brugué, Miquel (Hospital Universitari Vall d'Hebron) ;
Castelao, Enrique ;
Cervilla, Jorge A. ;
Chaumette, Boris ;
Cichon, Sven ;
Corvin, Aiden ;
Craddock, Nicholas ;
Craig, David ;
Degenhardt, Franziska ;
Djurovic, Srdjan ;
Edenberg, Howard J. ;
Fanous, Ayman H. ;
Foo, Jerome C. ;
Forstner, Andreas J. ;
Frye, Mark ;
Fullerton, Janice M. ;
Gatt, Justine M. ;
Gejman, Pablo V. ;
Giegling, Ina ;
Grabe, Hans J. ;
Green, Melissa J. ;
Grevet, Eugenio H. ;
Grigoroiu-Serbanescu, Maria ;
Gutierrez, Blanca ;
Guzman-Parra, Jose ;
Hamilton, Steven P. ;
Hamshere, Marian L. ;
Hartmann, Annette ;
Hauser, Joanna ;
Heilmann-Heimbach, Stefanie ;
Hoffmann, Per ;
Ising, Marcus ;
Jones, Ian ;
Jones, Lisa A. ;
Jonsson, Lina ;
Kahn, René S. ;
Kelsoe, John R. ;
Kendler, Kenneth S. ;
Kloiber, Stefan ;
Koenen, Karestan C. ;
Kogevinas, M ;
Konte, Bettina ;
Krebs, Marie-Odile ;
Landén, Mikael ;
Lawrence, Jacob ;
Leboyer, Marion ;
Lee, Phil H. ;
Levinson, Douglas F. ;
Liao, Calwing ;
Lissowska, Jolanta ;
Lucae, Susanne ;
Mayoral-Cleries, Fermín ;
McElroy, Susan L. ;
McGrath, Patrick ;
McGuffin, Peter ;
McQuillin, Andrew ;
Medland, Sarah E. ;
Mehta, Divya ;
Melle, Ingrid ;
Milaneschi, Yuri ;
Mitchell, Philip B. ;
Molina, Esther ;
Morken, Gunnar ;
Bo Mortensen, Preben ;
Müller-Myhsok, Bertram ;
Nievergelt, Caroline ;
Nimgaonkar, Vishwajit ;
Nöthen, Markus M. ;
O'Donovan, Michael C. (Cardiff University) ;
Ophoff, Roel A. ;
Owen, Michael J. ;
Pato, Carlos ;
Pato, Michele T. ;
Penninx, Brenda WJH ;
Pimm, Jonathan ;
Pistis, Giorgio ;
Potash, James B. ;
Power, Robert A. ;
Preisig, Martin ;
Quested, Digby ;
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron) ;
Reif, Andreas ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron) ;
Richarte, Vanesa (Hospital Universitari Vall d'Hebron) ;
Rietschel, Marcella ;
Rivera, Margarita ;
Roberts, Andrea ;
Roberts, Gloria ;
Rouleau, Guy A. ;
Rovaris, Diego L. ;
Rujescu, Dan ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron) ;
Sanders, Alan R. ;
Schofield, Peter R. ;
Schulze, Thomas G. ;
Scott, Laura J. ;
Serretti, Alessandro ;
Shi, Jianxin ;
Shyn, Stanley I. ;
Sirignano, Lea ;
Sklar, Pamela ;
Smeland, Olav B. ;
Smoller, Jordan W. ;
Sonuga-Barke, Edmund J.S. ;
Spalletta, Gianfranco ;
Strauss, John S. ;
Świątkowska, Beata ;
Trzaskowski, Maciej ;
Turecki, Gustavo ;
Vilar-Ribó, L (Hospital Universitari Vall d'Hebron) ;
Vincent, John B. ;
Völzke, Henry ;
Walters, James T.R. ;
Weickert, Cynthia Shannon ;
Weickert, Thomas W. ;
Weissman, Myrna M. ;
Williams, Leanne M. ;
Wray, Naomi R. ;
Zai, Clement C. ;
Ashley-Koch, Allison E. ;
Beckham, Jean C. ;
Hauser, Elizabeth R. ;
Hauser, Michael A. ;
Kimbrel, Nathan A. ;
Lindquist, Jennifer H. ;
McMahon, Benjamin ;
Oslin, David W. ;
Qin, Xuejun ;
Agerbo, Esben ;
Børglum, Anders D. ;
Breen, Gerome ;
Erlangsen, Annette ;
Esko, Tõnu ;
Gelernter, Joel ;
Hougaard, David M. ;
Kessler, Ronald C. ;
Kranzler, Henry R. ;
Li, Qingqin S. ;
Martin, Nicholas G. ;
McIntosh, Andrew M. ;
Mors, Ole ;
Nordentoft, Merete ;
Olsen, Catherine M. ;
Porteous, David ;
Ursano, Robert J. ;
Wasserman, Danuta ;
Werge, Thomas ;
Whiteman, David C. ;
Bulik, Cynthia M. ;
Coon, Hilary ;
Demontis, Ditte ;
Docherty, Anna R. ;
Kuo, Po-Hsiu ;
Lewis, Cathryn M. ;
Mann, J. John ;
Rentería, Miguel E. ;
Smith, Daniel J. ;
Stahl, Eli A. ;
Stein, Murray B. ;
Streit, Fabian ;
Willour, Virginia ;
Ruderfer, Douglas M. ;
Universitat Autònoma de Barcelona
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. [...]
2021 -  10.1016/j.biopsych.2021.05.029
Biological psychiatry, Vol. 91 (september 2021) , p. 313-327
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17 p, 1.3 MB |
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
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Ahluwalia, Tarunveer Singh (University of Copenhagen) ;
Prins, Bram Peter (University of Groningen) ;
Abdollahi, Mohammadreza (University of Groningen) ;
Armstrong, Nicola (Murdoch University) ;
Aslibekyan, Stella (University of Alabama at Birmingham School of Public Health) ;
Bain, Lisa J (Qimr Berghofer Medical Research Institute) ;
Jefferis, Barbara (University College London) ;
Baumert, Jens (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Beekman, Marian (Leiden University Medical Center) ;
Ben-Shlomo, Yoav (University of Bristol) ;
Bis, Joshua C (University of Washington) ;
Mitchell, Braxton D. (University of Maryland School of Medicine) ;
de Geus, Eco J. C (Amsterdam UMC. University Medical Center) ;
Delgado, Graciela E. (University of Heidelberg) ;
Marek, Diana (Sib Swiss Institute of Bioinformatics) ;
Eriksson, Joel (University of Gothenburg) ;
Kajantie, Eero (Helsinki University Central Hospital and University of Helsinki) ;
Kanoni, Stavroula (Queen Mary University of London) ;
Kemp, John P. (University of Bristol) ;
Lu, Chen (Boston University School of Public Health) ;
Marioni, Riccardo E. (University of Edinburgh) ;
McLachlan, Stela (University of Edinburgh) ;
Milaneschi, Yuri (Amsterdam Umc. Vrije Universiteit) ;
Nolte, Ilja M. (University of Groningen) ;
Petrelis, Alexandros M. (Université de Lorraine) ;
Porcu, Eleonora (Consiglio Nazionale Delle Ricerche) ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Naderi, Elnaz (University of Groningen) ;
Seppälä, Ilkka (Tampere University) ;
Shah, Tina (University College London) ;
Singhal, Gaurav (University of Adelaide) ;
Standl, Marie (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Teumer, Alexander (University Medicine Greifswald) ;
Thalamuthu, Anbupalam (University of New South Wales) ;
Thiering, Elisabeth (Ludwig-Maximilians-University of Munich. Dr. von Hauner Children's Hospital) ;
Trompet, Stella (Leiden University Medical Center) ;
Ballantyne, Christie M. (Baylor College of Medicine) ;
Benjamin, Emelia J. (Boston University School of Medicine) ;
Casas, Juan P. (Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC). Va Boston Healthcare System) ;
Toben, Catherine (University of Adelaide) ;
Dedoussis, George (Harokopio University) ;
Deelen, Joris (Max Planck Institute for Biology of Ageing) ;
Durda, Peter (Larner College of Medicine. University of Vermont) ;
Engmann, Jorgen (University College London) ;
Feitosa, Mary (Washington University School of Medicine) ;
Grallert, Harald (German Center for Diabetes Research (DZD)) ;
Hammarstedt, Ann (Sahlgrenska Academy at the University of Gothenburg) ;
Harris, Sarah E (University of Edinburgh) ;
Homuth, Georg (University Medicine Greifswald) ;
Hottenga, Jouke Jan (Amsterdam UMC. University Medical Center) ;
Jalkanen, Sirpa (University of Turku) ;
Jamshidi, Yalda (St George's University of London) ;
Jawahar, Magdalene C. (University of Adelaide) ;
Jess, Tine (Statens Serum Institute) ;
Kivimaki, Mika (University College London) ;
Kleber, Marcus E. (University of Heidelberg) ;
Lahti, Jari (University of Helsinki) ;
Liu, Yongmei (Wake Forest School of Medicine) ;
Marques-Vidal, Pedro (University of Lausanne) ;
Mellström, Dan (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ;
Mooijaart, Simon P. (Leiden University Medical Center) ;
Müller-Nurasyid, Martina (Johhanes Gutenberg University) ;
Penninx, Brenda WJH (Amsterdam Umc. Vrije Universiteit) ;
Revez, Joana A. (Qimr Berghofer Medical Research Institute) ;
Rossing, Peter (University of Copenhagen) ;
Raïkkönen, Katri (University of Helsinki) ;
Sattar, Naveed (Bhf Glasgow Cardiovascular Research Centre) ;
Scharnagl, Hubert (Medical University of Graz) ;
Sennblad, Bengt (Uppsala University) ;
Silveira, Angela (Karolinska Institutet (Estocolm, Suècia)) ;
Pourcain, Beate St (Radboud University) ;
Timpson, Nicholas J. (University of Bristol) ;
Trollor, Julian (University of New South Wales) ;
Van Dongen, Jenny (Amsterdam UMC. University Medical Center) ;
Van Heemst, Diana (Baylor College of Medicine) ;
Visvikis-Siest, Sophie (Université de Lorraine. Inserm. IGE-PCV) ;
Vollenweider, Peter (University of Lausanne) ;
Völker, Uwe (University of Turku) ;
Waldenberger, Melanie (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Willemsen, Gonneke (Amsterdam UMC. University Medical Center) ;
Zabaneh, Delilah (University College London Genetics Institute) ;
Morris, Richard W. (Bristol Medical School. University of Bristol) ;
Arnett, Donna K. (University of Kentucky) ;
Baune, Bernhard T. (University of Melbourne) ;
Boomsma, Dorret I. (Amsterdam UMC. University Medical Center) ;
Chang, Yen-Pei C. (University of Maryland School of Medicine) ;
Deary, Ian J. (University of Edinburgh) ;
Deloukas, Panos (Queen Mary University of London) ;
Eriksson, Johan G. (University of Helsinki) ;
Evans, David M. (University of Bristol) ;
Ferreira, Manuel A. (Qimr Berghofer Medical Research Institute) ;
Gaunt, Tom (University of Bristol) ;
Gudnason, Vilmundur (University of Iceland) ;
Hamsten, Anders (Karolinska Institutet (Estocolm, Suècia)) ;
Heinrich, Joachim (University of Melbourne) ;
Hingorani, Aroon (University College London) ;
Humphries, Steve E. (University College London) ;
Jukema, J. Wouter (Durrer Center for Cardiogenetic Research) ;
Koenig, Wolfgang (University of Ulm) ;
Kumari, Meena (University of Essex) ;
Kutalik, Zoltan (University of Lausanne) ;
Lawlor, Deborah A. (University of Bristol) ;
Lehtimäki, Terho (Tampere University) ;
März, Winfried (Synlab Academy. Synalb Holding Deutschland GmbH) ;
Mather, Karen A (Neuroscience Research Australia) ;
Naitza, Silvia. (Consiglio Nazionale Delle Ricerche) ;
Nauck, Matthias (Dzhk (German Center for Cardiovascular Research). Partner Site Greifswald) ;
Ohlsson, Claes (University of Gothenburg) ;
Price, Jackie F. (University of Edinburgh) ;
Raitakari, Olli (Turku University Hospital (Finlàndia)) ;
Rice, Ken (University of Washington) ;
Sachdev, Perminder S. (Prince of Wales Hospital (Australia)) ;
Slagboom, Pieternella Eline (Max Planck Institute for Biology of Ageing) ;
Sørensen, Thorkild I.A. (University of Copenhagen. Department of Public Health. Section on Epidemiology) ;
Spector, Tim (King's College London. Department of Twin Research and Genetic Epidemiology) ;
Stacey, David (University of Cambridge) ;
Stathopoulou, Maria G. (Université de Lorraine. Inserm. IGE-PCV) ;
Tanaka, Toshiko (National Institute on Aging (Estats Units d'Amèrica)) ;
Wannamethee, Sasiwarang Goya (University College London) ;
Whincup, Peter (University of London) ;
Rotter, Jerome I. (The Lundquist Institute at Harbor-UCLA Medical Center) ;
Dehghan, Abbas (Erasmus Mc) ;
Boerwinkle, Eric (Baylor College of Medicine) ;
Psaty, Bruce M. (University of Washington) ;
Snieder, Harold (University Medical Center Groningen) ;
Alizadeh, Behrooz Ziad (University Medical Center Groningen)
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. [...]
2021 - 10.1093/hmg/ddab023
Human Molecular Genetics, Vol. 30 Núm. 5 (january 2021) , p. 393-409
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