Niederwanger, Michael - Resultats de la cerca - Dipòsit Digital de Documents de la UAB

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Resultats globals: 4 registres trobats en 0.02 segons.
Articles, 4 registres trobats

Articles	4 registres trobats

12 p, 1.5 MB

The Modular Architecture of Metallothioneins Facilitates Domain Rearrangements and Contributes to Their Evolvability in Metal-Accumulating Mollusks / Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ; Pedrini-Martha, Veronika (University of Innsbruck. Department of Zoology) ; Niederwanger, Michael (University of Innsbruck. Department of Zoology) ; Dallinger, Reinhard (University of Innsbruck. Department of Zoology) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Albalat, Ricard (Universitat de Barcelona. Institut de Recerca de la Biodiversitat (IRBio))
Protein domains are independent structural and functional modules that can rearrange to create new proteins. While the evolution of multidomain proteins through the shuffling of different preexisting domains has been well documented, the evolution of domain repeat proteins and the origin of new domains are less understood. [...]
2022 - DOI (Digital Object Identifier)

10.3390/ijms232415824
International journal of molecular sciences, Vol. 23, Issue 24 (December 2022) , art. 15824

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15 p, 1.8 MB

Two Unconventional Metallothioneins in the Apple Snail Pomacea bridgesii Have Lost Their Metal Specificity during Adaptation to Freshwater Habitats / García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ; Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Niederwanger, Michael (University of Innsbruck. Institute of Zoology) ; Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Dallinger, Reinhard (University of Innsbruck. Institute of Zoology)
Metallothioneins (MTs) are a diverse group of proteins responsible for the control of metal homeostasis and detoxification. To investigate the impact that environmental conditions might have had on the metal-binding abilities of these proteins, we have characterized the MTs from the apple snail Pomacea bridgesii, a gastropod species belonging to the class of Caenogastropoda with an amphibious lifestyle facing diverse situations of metal bioavailability. [...]
2021 - DOI (Digital Object Identifier)

10.3390/ijms22010095
International journal of molecular sciences, Vol. 22, Issue 1 (January 2021) , art. 95

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15 p, 2.3 MB

Biomphalaria glabrata metallothionein : Lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding / Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck) ; Calatayud, Sara (Universitat de Barcelona. Departament de Biologia Evolutiva) ; Zerbe, Oliver (University of Zürich. Department of Chemistry) ; Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Biologia Evolutiva) ; Albalat, Ricard (Universitat de Barcelona. Departament de Biologia Evolutiva) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck)
The wild-type metallothionein (MT) of the freshwater snail Biomphalaria glabrata and a natural allelic mutant of it in which a lysine residue was replaced by an asparagine residue, were recombinantly expressed and analyzed for their metal-binding features with respect to Cd, Zn and Cu, applying spectroscopic and mass-spectrometric methods. [...]
2017 - DOI (Digital Object Identifier)

10.3390/ijms18071457
International journal of molecular sciences, Vol. 18, Num. 7 (July 2017) , art. 1457

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16 p, 2.3 MB

Analysis of metal-binding features of the wild type and two domain-truncated mutant variants of Littorina littorea metallothionein reveals its cd-specific character / Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Jiménez Martí, Elena (Universitat de Barcelona. Departament de Genètica) ; Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ; Gil-Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ; Zerbe, Oliver (University of Zurich. Institute of Organic Chemistry) ; Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica) ; Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
After the resolution of the 3D structure of the Cd9-aggregate of the Littorina littorea metallothionein (MT), we report here a detailed analysis of the metal binding capabilities of the wild type MT, LlwtMT, and of two truncated mutants lacking either the N-terminal domain, Lltr2MT, or both the N-terminal domain, plus four extra flanking residues (SSVF), Lltr1MT. [...]
2017 - DOI (Digital Object Identifier)

10.3390/ijms18071452
International journal of molecular sciences, Vol. 18 Núm. 7 (july 2017) , p. 1452

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