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1.
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11 p, 1.4 MB |
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
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Marques-Pamies, Montserrat (Hospital Municipal de Badalona) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández García, Marta (Hospital Universitari Arnau de Vilanova) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Giménez-Palop, Olga (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martínez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pons, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Taibo, Rocío (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Araujo-Castro, Marta (Hospital Ramón y Cajal) ;
Blanco, Concepción (Hospital Universitario Príncipe de Asturias) ;
Simón, Inmaculada (Hospital Universitari Joan XXIII de Tarragona) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pavón, Isabel (Hospital Universitario de Getafe) ;
García-Centeno, Rogelio (Hospital General Universitari Gregorio Marañón) ;
Zavala, Roxana (Hospital Universitari Joan XXIII de Tarragona) ;
Hanzu, Felicia A (Hospital Clínic i Provincial de Barcelona) ;
Mora, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Aulinas, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vilarrasa, Nuria (Instituto de Salud Carlos III) ;
Librizzi, Soledad (Hospital Universitario 12 de Octubre) ;
Calatayud, María (Hospital Universitario 12 de Octubre) ;
de Miguel, Paz (Hospital Clínico San Carlos (Madrid)) ;
Alvarez-Escola, Cristina (Hospital Universitario La Paz) ;
Picó Alfonso, Antonio M (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Sampedro, Miguel (Hospital Universitario de La Princesa) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Webb, S. M 1952- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
We previously described that a short version of the acute octreotide test (sAOT) can predict the response to first-generation somatostatin receptor ligands (SRLs) in patients with acromegaly. We have prospectively reassessed the sAOT in patients from the ACROFAST study using current ultra-sensitive GH assays. [...]
2023 -  10.3389/fendo.2023.1269787
Frontiers in Endocrinology, Vol. 14 (october 2023)
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2.
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8 p, 366.3 KB |
Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly
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Ruiz-Janer, Sabina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Venegas, Eva (Hospital Universitario Virgen del Rocío (Andalusia)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Garcia-Centeno, Rogelio (Hospital Universitario Gregorio Marañón) ;
Gálvez, María Ángeles (Hospital Universitario Reina Sofía (Andalusia)) ;
Picó Alfonso, Antonio M. (Hospital General Universitario de Alicante) ;
Maraver, Silvia (Hospital Universitario Virgen de la Victoria (Andalusia)) ;
González, Inmaculada (Hospital Regional Universitario de Málaga) ;
Abellán-Galiana, Pablo (Hospital General Universitario de Castelló) ;
Trincado, Pablo (Hospital Universitario Miguel Servet (Saragossa)) ;
Herrera, Mayte T. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Olvera, Pilar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bernabeu Morón, Ignacio (Complejo Universitario de Santiago de Compostela) ;
Serra-Soler, Guillermo (Hospital Universitari Son Espases (Illes Balears)) ;
Azriel, Sharona (Hospital Universitario Infanta Sofía (Madrid)) ;
García, Lourdes (Hospital Universitario de Jerez (Illes Canàries)) ;
Carvalho, Davide (Centro Hospitalar Universitário de São João (Portugal)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig, Josep (Hospital Universitari de Girona Doctor Josep Trueta) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objective: Hyperintensity signal in T2-weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment in acromegaly. The aim of the study was to evaluate T2 MRI signal intensity and its relation with pasireotide therapeutic effectiveness in real-life clinical practice. [...]
2023 - 10.1111/cen.14946
Clinical Endocrinology, Vol. 99 Núm. 4 (october 2023) , p. 378-385
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3.
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14 p, 1.9 MB |
Data mining analyses for precision medicine in acromegaly : a proof of concept
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol) ;
Sampedro, Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Picó Alfonso, Antonio M (Universidad Miguel Hernández de Elche. Departamento de Medicina Clínica) ;
García-Martínez, Araceli (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Martel-Duguech, Luciana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sardon, Teresa (Anaxomics Biotech S.L.) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Villabona, Carles (Hospital Universitari de Bellvitge) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Fajardo-Montañana, Carmen (Hospital de La Ribera (Alzira). Servicio de Endocrinología) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Lamas, Cristina (Hospital General Universitario de Albacete. Servicio de Endocrinología) ;
Alvarez, Clara V. (Universidade de Santiago de Compostela) ;
Bernabeu Morón, Ignacio (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig-Domingo, Manel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there is no consensus criterion on how to assign this pharmacologic treatment according to biomarker levels. [...]
2022 - 10.1038/s41598-022-12955-2
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 8979
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12 p, 1.3 MB |
ESE audit on management of adult growth hormone deficiency in clinical practice
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Martel-Duguech, Luciana (Institut d'Investigació Biomèdica Sant Pau) ;
Jorgensen, Jens Otto Lunde (Department of Clinical Medicine. Department of Endocrinology and Diabetes) ;
Korbonits, Marta (Queen Mary University of London) ;
Johannsson, Gudmundur (University of Gothenburg) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Adamidou, Fotini (Hippokration General Hospital of Thessaloniki) ;
Mintziori, Gesthimani (Hippokration General Hospital of Thessaloniki) ;
Arosio, Maura (University of Milan) ;
Giavoli, Claudia (University of Milan) ;
Badiu, Corin (National Institute of Endocrinology 'C. Davila') ;
Boschetti, Mara (University of Genoa) ;
Ferone, Diego (University of Genoa) ;
Bitti, Silvia Ricci (University of Genoa) ;
Brue, Thierry (Aix-Marseille Université) ;
Albarel, Frederique (Aix-Marseille Université) ;
Cannavo, Salvatore (University of Messina) ;
Carvalho, Davide (Universidade do Porto) ;
Salazar, Daniela Alves (Universidade do Porto) ;
Christ, Emanuel (University Hospital Basel (Basilea, Suïssa)) ;
Debono, Miguel (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Dusek, Tina (University Hospital Center Zagreb) ;
García-Centeno, Rogelio (Hospital General Universitario Gregorio Marañón) ;
Ghigo, Ezio (University of Turin) ;
Gasco, Valentina (University of Turin) ;
Góth, Miklós I. (Hungarian Defense Forces) ;
Olah, Dóra (Hungarian Defense Forces) ;
Kovacs, Laszlo (Hungarian Defense Forces) ;
Høybye, Charlotte (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Kocjan, Tomaz (Univerza V Ljubljani) ;
Kozamernik, Katarina Mlekuš (Univerza V Ljubljani) ;
Kužma, Martin (University Hospital Bratislava) ;
Payer, Juraj (University Hospital Bratislava) ;
Medić Stojanoska, Milica (University of Novi Sad) ;
Novak, Anela (University Hospital Center Split) ;
Miličević, Tanja (University Hospital Center Split) ;
Pekic, Sandra (University of Belgrade) ;
Milijic, Dragana (University of Belgrade) ;
Pérez Luis, Jesus (Universidad de La Laguna) ;
Picó Alfonso, Antonio M (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Preda, Veronica (Macquarie University) ;
Raverot, Gérald (Hôpital Louis Pradel) ;
Borson-Chazot, Francoise (Hôpital Louis Pradel) ;
Rochira, Vincenzo (Azienda Ospedaliero-Universitaria di Modena. Ospedale Civile di Baggiovara) ;
Monzani, Maria Laura (Azienda Ospedaliero-Universitaria di Modena. Ospedale Civile di Baggiovara) ;
Sandahl, Kristian (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Tsagarakis, Stylianos (Evangelismos General Hospital) ;
Mitravela, Vana (Evangelismos General Hospital) ;
Zacharieva, Sabina (Medical University - Sofia) ;
Zilatiene, Birute (Lithuanian University of Health Sciences) ;
Verkauskiene, Rasa (Lithuanian University of Health Sciences) ;
Universitat Autònoma de Barcelona
Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. Aims: (1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; (2) To evaluate educational status of healthcare professionals about AGHD. [...]
2021 - 10.1530/EJE-20-1180
European journal of endocrinology, Vol. 184 Núm. 2 (2021) , p. 323-334
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5.
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17 p, 24.9 MB |
Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Martínez, Araceli (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Rodríguez-Lloveras, Helena (Institut Germans Trias i Pujol) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Simó-Servat, Andreu (Mútua de Terrassa) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Picó Alfonso, Antonio M (Universidad de Miguel Hernández de Elche) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. [...]
2022 - 10.3390/biomedicines10020460
Biomedicines, Vol. 10 (february 2022)
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6.
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9 p, 714.0 KB |
Pasireotide in the Personalized Treatment of Acromegaly
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Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Endocrinology & Nutrition Service, Complejo Universitario de Santiago de Compostela) ;
Picó Alfonso, Antonio M (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez, María-Angeles (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Aller, Javier (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Universitat Autònoma de Barcelona
The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. [...]
2021 - 10.3389/fendo.2021.648411
Frontiers in Endocrinology, Vol. 12 (march 2021)
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