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Basis for enhanced barrier function of pigmented skin
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Man, Mao-Qiang (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Lin, Tzu-Kai (Graduate Institute of Clinical Medicine, National Cheng Kung University Medical College & Department of Dermatology, Tainan, Taiwan) ;
Santiago, Juan Luis (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Celli, Anna (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Zhong, Lily (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Huang, Zhi-Ming (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Roelandt, Truus (Department of Dermatology, Universitair Ziekenhuis Brussel, Brussels, Belgium) ;
Hupe, Melanie (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Sundberg, John P. (Department of Research and Development, The Jackson Laboratory, Bar Harbor, ME) ;
Silva, Kathleen A. (Department of Research and Development, The Jackson Laboratory, Bar Harbor, ME) ;
Crumrine, Debra (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Martin-Ezquerra, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Trullas, Carles (ISDIN, Research & Development, Barcelona, Spain) ;
Sun, Richard (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Wakefield, Joan S. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Wei, Maria L. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Feingold, Kenneth R. (Medical Service, Department of Veterans Affairs Medical Center, and Department of Metabolism, UCSF, San Francisco, CA) ;
Mauro, Theodora M. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Elias, Peter M. (Dermatology Service, Department of Veterans Affairs Medical Center, and Department of Dermatology, UCSF, San Francisco, CA) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Humans with darkly-pigmented skin display superior permeability barrier function in comparison to humans with lightly-pigmented skin. The reduced pH of the stratum corneum (SC) of darkly-pigmented skin could account for enhanced function, because acidifying lightly-pigmented human SC resets barrier function to darkly-pigmented levels. [...]
2014 - 10.1038/jid.2014.187
The Journal of investigative dermatology, Vol. 134 (april 2014) , p. 2399-2407
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