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Resultats globals: 5 registres trobats en 0.02 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
11 p, 3.1 MB Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections / Moreno-Molina, Miguel (Instituto de Biomedicina de Valencia (IBV-CSIC)) ; Shubladze, Natalia (National Center for Tuberculosis and Lung Diseases of Georgia) ; Khurtsilava, Iza (National Center for Tuberculosis and Lung Diseases of Georgia) ; Avaliani, Zaza (National Center for Tuberculosis and Lung Diseases of Georgia) ; Bablishvili, Nino (National Center for Tuberculosis and Lung Diseases of Georgia) ; Torres-Puente, Manuela (Instituto de Biomedicina de Valencia (IBV-CSIC)) ; Villamayor, Luis (FISABIO Public Health) ; Gabrielian, Andrei (National Institutes of Health. Department of Health and Human Services (Estats Units d'Amèrica)) ; Rosenthal, Alex (National Institutes of Health. Department of Health and Human Services (Estats Units d'Amèrica)) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gagneux, Sebastien (University of Basel) ; Kempker, Russell R. (Emory University School of Medicine. Department of Medicine) ; Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases of Georgia) ; Comas, I (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Universitat Autònoma de Barcelona
Polyclonal infections occur when at least two unrelated strains of the same pathogen are detected in an individual. This has been linked to worse clinical outcomes in tuberculosis, as undetected strains with different antibiotic resistance profiles can lead to treatment failure. [...]
2021 - 10.1038/s41467-021-22705-z
Nature communications, Vol. 12 (may 2021)  
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2.
18 p, 7.7 MB Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis / Moreira-Teixeira, Lúcia (The Francis Crick Institute, London) ; Stimpson, Philippa J. (The Francis Crick Institute, London) ; Stavropoulos, Evangelos (The Francis Crick Institute, London) ; Hadebe, Sabelo (The Francis Crick Institute, London) ; Chakravarty, Probir (The Francis Crick Institute, London) ; Ioannou, Marianna (The Francis Crick Institute, London) ; Aramburu, Iker Valle (The Francis Crick Institute, London) ; Herbert, Eleanor (The Francis Crick Institute, London) ; Priestnall, Simon L. (The Francis Crick Institute, London) ; Suarez-Bonnet, Alejandro (The Francis Crick Institute, London) ; Sousa, Jeremy (Universidade do Porto. ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Porto) ; Fonseca, Kaori L. (Instituto Gulbenkian de Ciência (IGC), Oeiras) ; Wang, Qian (The Francis Crick Institute, London) ; Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi) ; Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Saraiva, Margarida (Universidade do Porto. IBMC - Instituto de Biologia Molecular e Celular) ; Papayannopoulos, Venizelos (The Francis Crick Institute, London) ; O'Garra, Anne (Imperial College London)
Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. [...]
2020 - 10.1038/s41467-020-19412-6
Nature communications, Vol. 11 (november 2020)  
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3.
13 p, 3.5 MB Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils / Fonseca, Kaori L. (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Maceiras, Ana Raquel (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Matos, Rita (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Simoes-Costa, Luisa (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Sousa, Jeremy (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Cá, Baltazar (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Barros, Leandro (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Fernandes, Ana Isabel (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Mereiter, Stefan (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Reis, Ricardo (CDP-Centro de Diagnóstico Pneumológico do Porto) ; Gomes, Joana (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Martínez, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martín-Céspedes, Montse (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (NCTLD). Tbilisi) ; Gogishvili, Shota (National Center for Tuberculosis and Lung Diseases (NCTLD). Tbilisi) ; Nikolaishvili, Keti (National Center for Tuberculosis and Lung Diseases (NCTLD). Tbilisi) ; Appelberg, Rui (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Gärtner, Fátima (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Rodrigues, Pedro N. S. (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Reis, Celso A. (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Magalhães, Ana (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Saraiva, Margarida (Universidade do Porto. Instituto de Investigação e Inovação em Saúde) ; Universitat Autònoma de Barcelona
Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O -glycans biosynthesis, drives susceptibility to Mycobacterium tuberculosis infection. [...]
2020 - 10.1038/s41385-020-0277-7
Mucosal Immunology, Vol. 13 (march 2020) , p. 836-848  
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4.
11 p, 692.2 KB Impact of adjuvant therapeutic surgery on the health-related quality of life of pulmonary tuberculosis patients / Benito, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Gogishvili, Shota (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Nikolaishvili, Keti (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Despuig, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Tukvadze, Nestan (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Shubladze, Natalia (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Avaliani, Zaza (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia)) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
This study aimed to determine the health-related quality of life (HRQoL) of patients with pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In this scenario, the purpose was to elucidate and quantify the effect of various demographic, epidemiological, clinical, surgical and psychosocial details on this variable. [...]
2020 - 10.1183/23120541.00083-2020
ERJ Open Research, Vol. 6 (august 2020)  
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5.
19 p, 711.7 KB Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia / Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (NCTLD)) ; Despuig, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gogishvili, Shota (National Center for Tuberculosis and Lung Diseases (NCTLD), 50, Maruashvili Str. 0101 Tbilisi, Georgia) ; Nikolaishvili, Keti (National Center for Tuberculosis and Lung Diseases (NCTLD), 50, Maruashvili Str. 0101 Tbilisi, Georgia) ; Shubladze, Natalia (National Center for Tuberculosis and Lung Diseases (NCTLD), 50, Maruashvili Str. 0101 Tbilisi, Georgia) ; Avaliani, Zaza (National Center for Tuberculosis and Lung Diseases (NCTLD), 50, Maruashvili Str. 0101 Tbilisi, Georgia) ; Tukvadze, Nestan (National Center for Tuberculosis and Lung Diseases (NCTLD), 50, Maruashvili Str. 0101 Tbilisi, Georgia) ; Casals, Martí (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Caylà, Joan A.. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Our aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. Demographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB lesions removed, and outcome were recorded retrospectively from the 137 patients who underwent therapeutical surgery for their TB in Tbilisi, Georgia during 2014 and 2015. [...]
2016 - 10.1016/j.ijid.2016.12.009
International journal of infectious diseases, Vol. 56 (december 2016) , p. 200-207  
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