Web of Science: 5 cites, Scopus: 4 cites, Google Scholar: cites,
Impact of adjuvant therapeutic surgery on the health-related quality of life of pulmonary tuberculosis patients
Benito, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Gogishvili, Shota (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Nikolaishvili, Keti (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Despuig, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tukvadze, Nestan (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Shubladze, Natalia (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Avaliani, Zaza (National Center for Tuberculosis and Lung Diseases (Tbilisi, Geòrgia))
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data: 2020
Resum: This study aimed to determine the health-related quality of life (HRQoL) of patients with pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In this scenario, the purpose was to elucidate and quantify the effect of various demographic, epidemiological, clinical, surgical and psychosocial details on this variable. A prospective cohort of 40 patients undergoing therapeutic surgery for pulmonary TB (Study of Human Tuberculosis Lesions (SH-TBL) cohort) was recruited in Tbilisi, Georgia, between 2016 and 2018. HRQoL was assessed by administering the St George's Respiratory Questionnaire (SGRQ) and a novel psychosocial questionnaire, the BCN-Q, both at baseline and at 6 months post-surgery. A statistically and clinically significant improvement in the SGRQ total score was observed at follow-up, although it did not reach the values found for the healthy population. The differences between time points were statistically significant for the following groups: women, age <40 years, body mass index ≥20 kg·m −2, nonsmokers, drug-susceptible and drug-resistant participants, both new and relapsed patients, early culture negativisation, cases with a single lesion, either lesions <35 mm or ≥35 mm, and lesion, lobe and lung resections. The analysis of BCN-Q together with the SGRQ showed that several of its items, such as marital status, living conditions, nutrition, employment, external support, certain attitudes towards the healthcare system, emotional burden and sleep troubles, can impact HRQoL. These results highlight the benefit of adjuvant therapeutic surgery for pulmonary TB in selected patients in terms of HRQoL and suggest that a comprehensive approach including demographic, epidemiological, clinical and psychosocial variables may more accurately predict TB evolution and prognosis. Adjuvant therapeutic surgery in selected pulmonary TB patients improves their health-related quality of life. Impact of psychosocial variables on HRQoL may be assessed using a newly developed questionnaire, namely BCN-Q.
Ajuts: Agència de Gestió d'Ajuts Universitaris i de Recerca 2017 FI_B_00797
Nota: Altres ajuts: This study was funded by the Spanish Government-FEDER Funds through CV contracts CP13/00174, CPII14/00021 and PI16/01511 grant; the "CIBER Enfermedades Respiratorias" Network (CIBERES); the "Spanish Society of Pneumology and Thoracic Surgery" (SEPAR) through grant 16/023; and the "Agència de Gestió d'Ajuts Universitaris i de Recerca" (AGAUR) through AD contract (2017 FI_B_00797).
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Publicat a: ERJ Open Research, Vol. 6 (august 2020) , ISSN 2312-0541

DOI: 10.1183/23120541.00083-2020
PMID: 32904577
PMID: 32010722


11 p, 692.2 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
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 Registre creat el 2020-09-14, darrera modificació el 2023-10-01



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