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16 p, 2.0 MB |
Semen miRNAs Contained in Exosomes as Non-Invasive Biomarkers for Prostate Cancer Diagnosis
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Barceló, Maria (Hospital Universitari de Bellvitge) ;
Castells, Manel (Hospital Universitari de Bellvitge) ;
Bassas, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Vigués, Francesc (Hospital Universitari de Bellvitge) ;
Larriba, Sara (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
Although it is specific for prostatic tissue, serum prostate-specific antigen (PSA) screening has resulted in an over-diagnosis of prostate cancer (PCa) and many unnecessary biopsies of benign disease due to a well-documented low cancer specificity, thus improvement is required. [...]
2019 -  10.1038/s41598-019-50172-6
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 13772
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17 p, 1.9 MB |
The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery
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Mela, Virginia (Universidad de Málaga. Departamento de Medicina y Dermatologia) ;
Agüera, Zaida (Universitat de Barcelona. Departament d'Infermeria de Salut Pública, Salut Mental i Maternoinfantil) ;
Alvarez-Bermudez, Maria D. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Martín-Reyes, Flores (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Sánchez-García, Ana (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Oliva-Olivera, Wilfredo (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Tomé, Monica (Hospital Regional Universitario de Málaga) ;
Moreno-Ruiz, Francisco J. (Hospital Regional Universitario de Málaga) ;
Soler-Humanes, Rocío (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Fernández-Serrano, Jose L. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Sánchez-Gallegos, Pilar (Universidad de Málaga. Deparatmento de Especialidades Quirúrgicas, Bioquímica y Inmunologia) ;
Martínez-Moreno, Jose M. (Universidad de Málaga. Deparatmento de Especialidades Quirúrgicas, Bioquímica y Inmunologia) ;
Sancho-Marín, Raquel (Universidad de Málaga. Deparatmento de Especialidades Quirúrgicas, Bioquímica y Inmunologia) ;
Fernández-Aranda, Fernando (Universitat de Barcelona. Departament de Ciències Clíniques) ;
García-Fuentes, Eduardo (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Tinahones, Francisco J.. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Garrido-Sánchez, Lourdes (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. [...]
2023 - 10.3390/nu15194109
Nutrients, Vol. 15 Núm. 19 (2023) , art. 4109
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22 p, 4.7 MB |
Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples
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Olivan, M (Hospital Universitari Vall d'Hebron) ;
García, Marta (Institut de Recerca Sant Joan de Déu) ;
Suárez, Leticia (Hospital Universitari Vall d'Hebron) ;
Guiu, Marc (Institut de Recerca Biomèdica) ;
Gros, Laura (Hospital Universitari Vall d'Hebron) ;
Méndez Fernández, Olga (Hospital Universitari Vall d'Hebron) ;
Rigau, Marina (Hospital Universitari de Bellvitge) ;
Reventós, Jaume (Hospital Universitari de Bellvitge) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron) ;
Planas, Jacques (Hospital Universitari Vall d'Hebron) ;
de la Cruz, Xavier (Hospital Universitari Vall d'Hebron) ;
Gomis, Roger R. (Hospital Universitari de Bellvitge) ;
Morote Robles, Juan (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Barrueco, Ruth (Hospital Universitari de Bellvitge) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Prostate cancer (PCa) is the most prevalent cancer in males worldwide, and it was the fifth leading cause of cancer mortality in this group in 2020. Near 70% of advanced-stage PCa patients will undergo bone metastasis, suffering pathological complications that severely affect patients' quality of life and probably progress in most cases to lethal PCa. [...]
2021 - 10.3390/cancers13246202
Cancers, Vol. 13 (december 2021)
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16 p, 1.3 MB |
The Intricate Interplay between Cancer Stem Cells and Oncogenic miRNAs in Breast Cancer Progression and Metastasis
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Tsintarakis, Antonis (National Hellenic Research Foundation) ;
Papalouka, Chara (National Hellenic Research Foundation) ;
Kontarini, Christina (National Hellenic Research Foundation) ;
Zoumpourlis, Panagiotis (National Hellenic Research Foundation) ;
Karakostis, Konstantinos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Adamaki, Maria (National Hellenic Research Foundation) ;
Zoumpourlis, Vassilis (National Hellenic Research Foundation)
Complex signaling interactions between cancer cells and their microenvironments drive the clonal selection of cancer cells. Opposing forces of antitumor and tumorigenic potential regulate the survival of the fittest clones, while key genetic and epigenetic alterations in healthy cells force them to transform, overcome cell senescence, and proliferate in an uncontrolled manner. [...]
2023 - 10.3390/life13061361
Life, Vol. 13 (june 2023)
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14 p, 2.6 MB |
Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids
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Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III) ;
Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz) ;
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Valero, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Olaguibel, José M. (Complejo Hospitalario de Navarra) ;
Del Pozo, Victoria (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. [...]
2023 - 10.3390/ijms24021611
International journal of molecular sciences, Vol. 24 (january 2023)
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18 p, 1.2 MB |
The Biomarker Potential of miRNAs in Myotonic Dystrophy Type I
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Koehorst, Emma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballester-Lopez, Alfonsina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arechavala-Gomeza, Virginia (Ikerbasque, Basque Foundation for Science) ;
Martínez-Piñeiro, Alicia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
MicroRNAs (miRNAs) are mostly known for their gene regulation properties, but they also play an important role in intercellular signaling. This means that they can be found in bodily fluids, giving them excellent biomarker potential. [...]
2020 - 10.3390/jcm9123939
Journal of clinical medicine, Vol. 9 (december 2020)
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9 p, 2.0 MB |
Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel
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Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Rendina, M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ;
Mazza, T. (Fondazione IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ;
Valori, V. M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Morritti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Anatomia Patologica) ;
Murgo, R. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Chirurgia Senologica) ;
Fazio, V. M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ;
Universitat Autònoma de Barcelona
MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospective cohort of breast cancer patients with a median follow-up of 76 months (n = 283). [...]
2019 - 10.1038/s41598-019-51581-3
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 14913
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