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Articles publicats 8 registres trobats  La cerca s'ha fet en 0.01 segons. 
1.
16 p, 586.7 KB Quantifying In-Host Quasispecies Evolution / Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibañez-Lligoña, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. [...]
2023 - 10.3390/ijms24021301
International journal of molecular sciences, Vol. 24 (january 2023)  
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2.
14 p, 2.6 MB Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids / Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ; Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III) ; Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz) ; Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz) ; Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ; Caballero, María L. (Hospital Universitario La Paz (Madrid)) ; González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela) ; Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ; Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ; Valero, Antonio (Hospital Clínic i Provincial de Barcelona) ; Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ; Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ; Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ; Olaguibel, José M. (Complejo Hospitalario de Navarra) ; Del Pozo, Victoria (Universidad Autónoma de Madrid) ; Universitat Autònoma de Barcelona
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. [...]
2023 - 10.3390/ijms24021611
International journal of molecular sciences, Vol. 24 (january 2023)  
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3.
18 p, 4.1 MB Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer / Muley, Helena (Universitat Internacional de Catalunya) ; Valencia, Karmele (Universidad de Navarra) ; Casas, Josefina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Moreno, Bea (Universidad de Navarra) ; Botella, Luis (Universitat Internacional de Catalunya. Departament de Ciències Bàsiques) ; Lecanda, Fernando (Universidad de Navarra) ; Fadó, Rut (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Casals, Nuria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to patient survival. [...]
2023 - 10.3390/ijms24020946
International journal of molecular sciences, Vol. 24 (january 2023)  
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4.
17 p, 11.0 MB Repair of Long Peripheral Nerve Defects in Sheep : A Translational Model for Nerve Regeneration / Contreras, Estefania (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Traserra Call, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Bolívar Martín, Sara (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Forés, Joaquím (Hospital Clínic i Provincial de Barcelona) ; José Cunilleras, Eduard (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Delgado Martínez, Ignacio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; García Arnas, Félix (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Udina i Bonet, Esther (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Navarro, X. (Xavier) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Despite advances in microsurgery, full functional recovery of severe peripheral nerve injuries is not commonly attained. The sheep appears as a good preclinical model since it presents nerves with similar characteristics to humans. [...]
2023 - 10.3390/ijms24021333
International journal of molecular sciences, Vol. 24 (january 2023)  
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5.
20 p, 2.2 MB Obtaining miRNA from Saliva-Comparison of Sampling and Purification Methods / Urbizu, Aintzane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Arnaldo, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Beyer, Katrin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The use of saliva as a biomarker source has advantages over other biofluids and imaging techniques, and miRNAs are ideal biomarker candidates. They are involved in numerous cellular processes, and their altered expression suggests that miRNAs play a crucial regulatory role in disease development. [...]
2023 - 10.3390/ijms24032386
International journal of molecular sciences, Vol. 24 (january 2023)  
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6.
17 p, 942.7 KB Gut Microbiota-Derived TMAO : A Causal Factor Promoting Atherosclerotic Cardiovascular Disease? / Canyelles, Marina (Institut d'Investigació Biomèdica Sant Pau) ; Borràs, Carla (Institut de Recerca Sant Pau) ; Rotllan, Noemi (Institut de Recerca Sant Pau) ; Tondo, Mireia (Institut de Recerca Sant Pau) ; Escolà-Gil, Joan Carles (Institut de Recerca Sant Pau) ; Blanco Vaca, Francisco (Institut de Recerca Sant Pau) ; Universitat Autònoma de Barcelona
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) and related complications, such as cardiovascular mortality or major adverse cardiovascular events (MACE). [...]
2023 - 10.3390/ijms24031940
International journal of molecular sciences, Vol. 24 (january 2023)  
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7.
17 p, 2.2 MB The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats / Estévez, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Institut de Neurociències)
Toll-like receptors (TLRs)-mediated host-bacterial interactions participate in the microbial regulation of gastrointestinal functions, including the epithelial barrier function (EBF). We evaluated the effects of TLR7 stimulation on the colonic EBF in rats. [...]
2023 - 10.3390/ijms24021254
International journal of molecular sciences, Vol. 24, Num. 2 (January 2023) , art. 1254  
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8.
16 p, 5.1 MB Exploring the Biological Properties of Zn(II) Bis thiosemicarbazone Helicates / Fernández-Fariña, Sandra (Universidade de Santiago de Compostela) ; Velo-Heleno, Isabel (Universidade de Santiago de Compostela) ; Carballido, Rocío (Universidade de Santiago de Compostela) ; Martínez-Calvo, Miguel (Universidade de Santiago de Compostela) ; Barcia, Ramiro (Universidade de Santiago de Compostela) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; González-Noya, Ana M. (Universidade de Santiago de Compostela) ; Pedrido, Rosa (Universidade de Santiago de Compostela)
The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bis thiosemicarbazone ligands with different terminal groups, Zn(L Me)∙2HO 1, Zn(L Ph)∙2HO 2 and Zn(L PhNO2) 3, obtained by an electrochemical methodology. [...]
2023 - 10.3390/ijms24032246
International journal of molecular sciences, Vol. 24, Num. 3 (January 2023) , art. 2246  
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