Web of Science: 4 cites, Scopus: 5 cites, Google Scholar: cites,
Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids
Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III)
Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz)
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz)
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid))
Caballero, María L. (Hospital Universitario La Paz (Madrid))
González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela)
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona)
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona)
Valero, Antonio (Hospital Clínic i Provincial de Barcelona)
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron)
Cruz, María Jesús (Hospital Universitari Vall d'Hebron)
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Olaguibel, José M. (Complejo Hospitalario de Navarra)
Del Pozo, Victoria (Universidad Autónoma de Madrid)
Universitat Autònoma de Barcelona

Data: 2023
Resum: Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. For this purpose, serum and lung tissue miRNAs of OCS and non-OCS asthmatic individuals were evaluated by miRNAs-Seq, and subsequently miRNA validation was performed using RT-qPCR. Additionally, pathway enrichment analysis of deregulated miRNAs was conducted. We observed altered expression by the next-generation sequencing (NGS) of 11 miRNAs in serum, of which five (hsa-miR-148b-3p, hsa-miR-221-5p, hsa-miR-618, hsa-miR-941, and hsa-miR-769-5p) were validated by RT-qPCR, and three miRNAs in lung tissue (hsa-miR-144-3p, hsa-miR-144-5p, and hsa-miR-451a). The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR-221-5p and hsa-miR-769-5p. Expression of hsa-miR-148b-3p and hsa-miR-221-5p correlated with FEV/FVC (%) and these altered miRNAs act in key signaling pathways for asthma disease and the regulated expression of some genes (FOXO3, PTEN, and MAPK3) involved in these pathways. In conclusion, there are miRNA profiles differentially expressed in OCS-treated individuals with asthma and could be used as biomarkers of OCS treatment.
Ajuts: Instituto de Salud Carlos III PI18/00167
Instituto de Salud Carlos III PI21/00896
Instituto de Salud Carlos III FI19/00067
Ministerio de Ciencia e Innovación RTC-2017-6501-1
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Biomarker ; Oral corticosteroids ; Mirnas ; Individuals with severe asthma
Publicat a: International journal of molecular sciences, Vol. 24 (january 2023) , ISSN 1422-0067

DOI: 10.3390/ijms24021611
PMID: 36675122


14 p, 2.6 MB

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 Registre creat el 2023-01-26, darrera modificació el 2024-02-28



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