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18 p, 2.2 MB |
Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
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Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vergara-Alert, Júlia (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Amengual-Rigo, Pep (Barcelona Supercomputing Center. Life Sciences Department) ;
Ainsua-Enrich, Erola (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brustolin, Marco (Institute of Tropical Medicine. Present Address: Department of Biomedical Sciences) ;
Rodríguez de la Concepción, María Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pedreño-López, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodon, Jordi (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez, Mònica (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Roca, Núria (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Tarrés-Freixas, Ferran (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Cantero, Guillermo (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Pons-Grífols, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rovirosa, Carla (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Aguilar-Gurrieri, Carmen (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ortiz, Raquel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Barajas Vélez, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lepore, Rosalba (Barcelona Supercomputing Center. Life Sciences Department) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Valencia, Alfonso (Universitat de Vic - Central de Catalunya) ;
Blanco, Julià (Universitat de Vic - Central de Catalunya) ;
Guallar, Victor (Institució catalana de Recerca i Estudis Avançats) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ;
Carrillo, Jorge (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of the Spike glycoprotein [K986P/V987P (S-2P)] with improved stability, yield and immunogenicity. [...]
2024 -  10.1038/s41467-024-46714-w
Nature communications, Vol. 15 (march 2024)
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4 p, 111.4 KB |
SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria
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Griffin, Morag (Department of Hematology. St James University Hospitals) ;
Eikema, Dirk-Jan (EBMT Statistical Unit) ;
Verheggen, Inge (EBMT Leiden Study Unit) ;
Kulagin, Alexander (Pavlov University) ;
Tjon, Jennifer M-L (Department of Hematology. Leiden University Medical Center) ;
Fattizzo, Bruno (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Ingram, Wendy (Department of Hematology. University Hospital of Wales) ;
Zaidi, Uzma (National Institute of Blood Disease & Bone Marrow Transplantation) ;
Desnica, Lana (Department of Hematology. University Hospital Center Zagreb) ;
Giammarco, Sabrina (Dipartimento di Diagnostica per Immagini. Radioterapia Oncologica ed Ematologia. Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Drozd-Sokolowska, Joanna (Department of Hematology. Medical University of Warsaw) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Patriarca, Andrea (AOU Maggiore della Carità (Itàlia)) ;
Loschi, Michael (Cote d'Azur University) ;
Szmigielska-Kaplon, Anna (Department of Hematology. Copernicus Hospital) ;
Beier, F. (RWTH Aachen University) ;
Cignetti, Alessandro (University Division of Hematology) ;
Drexler, Beatrice (University Hospital Basel (Basilea, Suïssa)) ;
Gavriilaki, Eleni (Department of Hematology. George Papanicolaou General Hospital) ;
Lanza, Francesco (Hospital Santa Maria delle Croci) ;
Orvain, Corentin (Centre Hospitalier Universitaire d'Angers) ;
Risitano, Antonio Maria (Department of Hematology. AORN Moscati) ;
de la Camara, Rafael (Hospital Universitario de la Princesa (Madrid)) ;
Peffault de Latour, Régis (Hôpital Saint-Louis)
2024 - 10.3324/haematol.2023.283863
Haematologica, Vol. 109 Núm. 1 (january 2024) , p. 283-286
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26 p, 1021.9 KB |
Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact
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Jungbluth, Stefan (European Vaccine Initiative) ;
Martin, William (European Vaccine Initiative) ;
Slezak, Monika (European Vaccine Initiative) ;
Depraetere, Hilde (European Vaccine Initiative) ;
Guzman, Carlos A. (Helmholtz Centre for Infection Research) ;
Ussi, Anton (EATRIS- European Research Infrastructure for Translational Medicine) ;
Morrow, David (EATRIS- European Research Infrastructure for Translational Medicine) ;
Van Heuverswyn, Fran (Flanders Vaccine) ;
Arnouts, Sven (Ghent University) ;
Carrondo, Manuel J. T. (Instituto de Biologia Experimental e Tecnológica) ;
Olesen, Ole (European Vaccine Initiative) ;
Ottenhoff, Tom H.M. (Leiden University Medical Center) ;
Dockrell, H. M. (London School of Hygiene & Tropical Medicine) ;
Ho, Mei Mei (Medicines and Healthcare products Regulatory Agency) ;
Dobly, Alexandre (Sciensano) ;
Christensen, Dennis (Statens Serum Institut) ;
Segalés Coma, Joaquim (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Laurent, Fabrice (Université François Rabelais de Tours) ;
Lantier, Frédéric (Université François Rabelais de Tours) ;
Stockhofe-Zurwieden, Norbert (Wageningen Bioveterinary Research) ;
Morelli, Francesca (CIRMMP) ;
Langermans, Jan A.M. (Biomedical Primate Research Centre) ;
Verreck, Frank A.W. (Biomedical Primate Research Centre) ;
Le Grand, Roger (Université Paris-Saclay) ;
Sloots, Arjen (Intravacc) ;
Medaglini, Donata (University of Siena) ;
Lawrenz, Maria (Vaccine Formulation Institute) ;
Collin, Nicolas (Vaccine Formulation Institute)
Research infrastructures are facilities or resources that have proven fundamental for supporting scientific research and innovation. However, they are also known to be very expensive in their establishment, operation and maintenance. [...]
2023 - 10.12688/f1000research.141399.1
F1000Research, Vol. 12 (october 2023)
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11 p, 1.4 MB |
A multistakeholder development process to prioritize and translate COVID-19 health recommendations for patients, caregivers and the public. A case study of the COVID-19 recommendation map
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Pottie, Kevin (Western University) ;
Smith, Maureen (Cochrane Consumer Network Executive) ;
Matthews, Micayla (McMaster University (Canadà)) ;
Santesso, Nancy (McMaster University (Canadà)) ;
Magwood, Olivia (University of Ottawa) ;
Kredo, Tamara (Stellenbosch University) ;
Scott, Sarah (McMaster University (Canadà)) ;
Bayliss, Kerin (National Institute for Health and Care Excellence) ;
Saad, Ammar (University of Ottawa) ;
Haridas, Rinila (University of Ottawa) ;
Detambel, Nicole (McMaster University (Canadà)) ;
Motilall, Ashley (McMaster University (Canadà)) ;
Tan, Yvonne (University of Ottawa) ;
Steinberg, Sally (Lancaster High School) ;
Litynska, Justyna (Evidence Prime. Inc.) ;
Dietl, Bart (Evidence Prime. Inc.) ;
Iorio, Alfonso (McMaster University (Canadà)) ;
Reveiz, Ludovic (Pan American Health Organization) ;
Welch, Vivian (University of Ottawa) ;
Klugar, Miloslav (Czech National Centre for Evidence-Based Healthcare and Knowledge Translation Brno) ;
Mbuagbaw, Lawrence (Cochrane South Africa) ;
Rojas-Reyes, Maria Ximena (Institut d'Investigació Biomèdica Sant Pau) ;
Florez, Ivan D (Clinica Las Americas-AUNA) ;
Lotfi, Tamara (McMaster University (Canadà)) ;
Qaseem, Amir (American College of Physicians) ;
Mathew, Joseph L. (Postgraduate Institute of Medical Education and Research) ;
Akl, Elie A (American University of Beirut) ;
Tugwell, Peter (University of Ottawa) ;
Schünemann, Holger J. (McMaster University (Canadà)) ;
Universitat Autònoma de Barcelona
To develop a digital communication tool to improve the implementation of up-to-date COVID-19 recommendations. Specifically, to improve patient, caregiver and public understanding of healthcare recommendations on prevention, diagnoses and treatment. [...]
2022 - 10.1016/j.jclinepi.2022.04.012
Journal of clinical epidemiology, Vol. 148 (august 2022) , p. 104-114
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11 p, 893.9 KB |
SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders
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Piñana, José Luis (Fundación INCLIVA. Instituto de Investigación Sanitaria Hospital Clínico Universitario de Valencia) ;
López-Corral, Lucía (Hospital Clínico Universitario (Salamanca)) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Vazquez, Lourdes (Hospital Clínico Universitario (Salamanca)) ;
Pérez, Ariadna (Fundación INCLIVA. Instituto de Investigación Sanitaria Hospital Clínico Universitario de Valencia) ;
Martin-Martin, Gabriel Andres (Hospital Clínico Universitario (Salamanca)) ;
Gago, Beatriz (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Sanz-Linares, Gabriela (Institut Català Oncologia-Hospital Duran i Reynals. Institut d'Investigació Biomèdica de Bellvitge) ;
Sánchez Salinas, Andrés (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Villalon, Lucia B. (Hospital Universitario Fundación Alcorcón) ;
Conesa-García, Venancio (Hospital General Universitario de Elche) ;
Olave, María Teresa (Hospital Clínico Universitario Lozano Blesa. Instituto de Investigacón Sanitaria Aragón) ;
Corona de Lapuerta, Magdalena (Hospital Universitario Ramón y Cajal (Madrid)) ;
Marcos-Corrales, Sara (Hospital Clínico Universitario (Salamanca)) ;
Tormo, Mar (Instituto de Investigación Sanitaria Fundación Para la Investigación del Hospital Clínico de Valencia) ;
Hernandez-Rivas, JA (Hospital Universitario Infanta Leonor) ;
Montoro, Juan B. (Hospital Universitari y politècnic La Fe (València)) ;
Rodríguez-Fernández, Alicia (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Risco-Gálvez, Irene (Hospital Arnau de Vilanova (València)) ;
Rodríguez-Belenguer, Pablo (Research Program on Biomedical Informatics (GRIB). Institut Hospital del Mar d'Investigacions Mèdiques. Universitat Pompeu Fabra) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínic Universitari (València)) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Ruíz-García, Montserrat M. (Hospital General Universitario de Elche) ;
Muñoz-Bellido, Juan Luis (Hospital Clínico Universitario (Salamanca)) ;
Solano, Carlos (Hospital Clínic Universitari (València)) ;
Cedillo Cedillo, Angel (Hematopoietic Stem Cell Transplantation and Cell Therapy Group) ;
Sureda, Anna (Institut Català Oncologia-Hospital Duran i Reynals. Institut d'Investigació Biomèdica de Bellvitge) ;
Navarro, David (Hospital Clínic Universitari (València))
Background: The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods: A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3-6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. [...]
2022 - 10.1186/s13045-022-01275-7
Journal of hematology & oncology, Vol. 15 Núm. 1 (december 2022) , p. 54
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61 p, 782.5 KB |
Vaccines for the common cold
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Montesinos-Guevara, Camila (Cochrane Ecuador. Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC). Facultad de Ciencias de la Salud Eugenio Espejo. Universidad UTE) ;
Buitrago-Garcia, Diana (Institute of Social and Preventive Medicine (ISPM). Graduate School of Health Sciences. University of Bern) ;
Felix, Maria L. (Universidad UTE. Departamento de Neonatología. Facultad de Ciencias de la Salud Eugenio Espejo) ;
Guerra, Claudia V. (Cochrane Ecuador. Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC). Facultad de Ciencias de la Salud Eugenio Espejo. Universidad UTE) ;
Hidalgo, Ricardo (Cochrane Ecuador. Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC). Facultad de Ciencias de la Salud Eugenio Espejo. Universidad UTE) ;
Martinez-Zapata, Maria José (Institut d'Investigació Biomèdica Sant Pau) ;
Simancas-Racines, Daniel (Cochrane Ecuador. Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC). Facultad de Ciencias de la Salud Eugenio Espejo. Universidad UTE)
Background: The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, sneezing, cough, malaise, sore throat, and fever (usually < 37. [...]
2022 - 10.1002/14651858.CD002190.pub6
The Cochrane library, Vol. 2022 Núm. 12 (December 2022) , p. CD002190
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7 p, 2.1 MB |
Online Information of Vaccines : Information Quality, Not Only Privacy, Is an Ethical Responsibility of Search Engines
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Ghezzi, Pietro (Brighton Sussex Medical School) ;
Bannister, Peter G. (Brighton Sussex Medical School) ;
Casino, Gonzalo (Institut d'Investigació Biomèdica Sant Pau) ;
Catalani, Alessia (University of Urbino Carlo Bo) ;
Goldman, Michel (Université Libre de Bruxelles) ;
Morley, Jessica (University of Oxford) ;
Neunez, Marie (Université Libre de Bruxelles) ;
Prados-Bo, Andreu. (Ramon Llull University) ;
Smeesters, Pierre R. (Université libre de Bruxelles) ;
Taddeo, Mariarosaria (The Alan Turing Institute) ;
Vanzolini, Tania (University of Urbino Carlo Bo) ;
Floridi, Luciano (The Alan Turing Institute) ;
Universitat Autònoma de Barcelona
The fact that Internet companies may record our personal data and track our online behavior for commercial or political purpose has emphasized aspects related to online privacy. This has also led to the development of search engines that promise no tracking and privacy. [...]
2020 - 10.3389/fmed.2020.00400
Frontiers in Medicine, Vol. 7 (november 2020) , p. 400
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11 p, 918.0 KB |
Brief Research Report : Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination
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Sisteré-Oró, Marta (Universitat Pompeu Fabra) ;
Wortmann, Diana D. J. (Universitat Pompeu Fabra) ;
Andrade, Naína (Universitat Pompeu Fabra) ;
Aguilar-Hernández, Andrés (Hospital Quiron-Dexeus Barcelona) ;
Mayo de las Casas, Clara (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Casabal, Florencia Garcia (Hospital Quiron-Dexeus Barcelona) ;
Torres, Susana (Hospital Quiron-Dexeus Barcelona) ;
Bona Salinas, Eduardo (Hospital Quiron-Dexeus Barcelona) ;
Raventos Soler, Laura (Hospital Quiron-Dexeus Barcelona) ;
Arcas, Andrea (Hospital Quiron-Dexeus Barcelona) ;
Esparre, Carlos (Hospital Quiron-Dexeus Barcelona) ;
Garcia, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Valarezo, Joselyn (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Güerri-Fernández, Robert (Hospital del Mar (Barcelona, Catalunya)) ;
Gonzalez-Cao, Maria (Hospital Quiron-Dexeus Barcelona) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. [...]
2022 - 10.3389/fimmu.2022.908108
Frontiers in immunology, Vol. 13 (july 2022)
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20 p, 1.1 MB |
Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies
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Hameed, Sodiq A. (Université Claude Bernard Lyon 1) ;
Paul, Stephane (Université Claude Bernard Lyon 1) ;
Dellosa, Giann Kerwin Y. (Université Claude Bernard Lyon 1) ;
Jaraquemada, Dolores (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Bello, Muhammad Bashir (Usmanu Danfodiyo University PMB)
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19 pandemic owing to rapid development, effectiveness, and scalability to meet the global demand. There are many other mRNA vaccines currently being developed against different emerging viral diseases. [...]
2022 - 10.1038/s41541-022-00485-x
NPJ Vaccines, Vol. 7 (june 2022)
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