Centre de Recerca en Sanitat Animal (CReSA-IRTA)


The Centre de Recerca en Sanitat Animal (CReSA) is the animal health research program of Institut de Recerca i Tecnologia Agroalimentàries (IRTA), its hosting institution. IRTA is a research institute owned by the Government of Catalonia (Spain) ascribed to the Department of Agriculture, Livestock, Fisheries and Food (DARP), which is also a CERCA institute.

CReSA activity is executed at the Edifici CReSA, which is a technologically advanced building, with conventional laboratories as well as biocontainment with level-3 biosafety (BSL-3) laboratories and animal facilities. CReSA is located within the campus of the UAB (Barcelona, Spain).

CReSA together with the BSL3 infrastructure of Centro de Investigación en Sanidad Animal (CISA-INIA), configures the so-called Red de Laboratorios de Alta Seguridad Biológica (RLASB, www.rlasb.es , High Biological Security Laboratories Network). The RLASB is a singular scientific and technological infrastructure (ICTS) of the Spanish Government. CReSA is also participating in the Red de Laboratorios de Alerta Biológica (RE-LAB, Biological Alert Laboratory Network), at Spanish level, and is one of the corner-stones of animal disease surveillance for the Catalan government. Recently, CReSA has been recognized as OIE Collaborating Centre for research and control for emerging and re-emerging swine diseases in Europe and OIE Reference Centre for Classical Swine Fever.

The research at CReSA is being performed under the umbrella of three major activities: basic and applied independent research based on national and international projects (organized in 3 research subprograms on epidemiology and risk assessment, endemic diseases and transboundary diseases), services for public administrations and research contracts with agri-food sector companies.

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2021-07-12
04:12
11 p, 2.1 MB Phylogenetic relationships investigation of Mycobacterium caprae strains from sympatric wild boar and goats based on whole genome sequencing / Ciaravino, Giovanna (Universitat Autònoma de Barcelona) ; Vidal Barba, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Cortey, Martí (Universitat Autònoma de Barcelona) ; Martín, Maite (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Sanz, Albert (Departament d'Agricultura, Ramaderia, Pesca i Alimentació de la Generalitat de Catalunya) ; Mercader, Irene (Departament d'Agricultura, Ramaderia, Pesca i Alimentació de la Generalitat de Catalunya) ; Perea, Claudia (United States Department of Agriculture) ; Robbe-Austerman, Suelee (United States Department of Agriculture) ; Allepuz Palau, Alberto (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Pérez de Val, Bernat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Tuberculosis (TB) in wildlife challenges epidemiological surveillance and disease control. An outbreak of TB was detected in a free-ranging wild boar population of a Natural Park in Catalonia (Spain) and the outbreak investigation was conducted in the area. [...]
2020 - 10.1111/tbed.13816
Transboundary and Emerging Diseases, Vol. 68 (september 2020) , p. 1476-1486  
2021-05-10
12:10
13 p, 816.0 KB Environmental and management factors affecting the time budgets of free-ranging iberian pigs reared in Spain / Martínez Macipe, Míriam (Institut de Recerca i Tecnologia Agroalimentàries (IRTA)) ; Mainau Brunsó, Eva (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Manteca Vilanova, Xavier (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Dalmau Bueno, Antoni (Institut de Recerca i Tecnologia Agroalimentàries (IRTA))
Understanding the natural behaviour of pigs in free-range conditions facilitates interpretation of their behaviour in intensive conditions. Studying six different farms over two years at different seasons, with climatic and management variations, allowed for a general description of Iberian pig behaviour and which factors have an influence on it. [...]
2020 - 10.3390/ani10050798
Animals, Vol. 10 Núm. 5 (may 2020) , p. 798  
2021-04-12
06:49
10 p, 349.7 KB The use of H-index to assess research priorities in poultry diseases / Bertran, Kateri (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Cortey, Martí (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Díaz, Ivan. (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Identifying which diseases represent a priority is crucial to optimize resources for diagnostics, control, and prevention. Here, the impact of 111 poultry pathogens belonging to Viruses (n = 31), Bacteria (n = 33), and Other (n = 47) was assessed using the H-index. [...]
2020 - 10.1016/j.psj.2020.09.017
Poultry Science, Vol. 99 (september 2020) , p. 6503-6512  
2021-04-12
06:49
4 p, 480.3 KB Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity / Bocharov, Gennady (Sechenov First Moscow State Medical University) ; Casella, Valentina (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Argilaguet, Jordi (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Grebennikov, Dmitry (Sechenov First Moscow State Medical University) ; Güerri-Fernández, Robert (Institut Hospital del Mar d'Investigacions Mèdiques) ; Ludewig, Burkhard (Kantonsspital St. Gallen) ; Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
2020 - 10.3389/fcimb.2020.559209
Frontiers in cellular and infection microbiology, Vol. 10 (october 2020)  
2021-04-12
06:49
4 p, 721.0 KB Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain / Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Puig, Mariona (Hospital Veterinari Sant Mori S.L) ; Rodon, Jordi (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cantero, Guillermo (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Terrón, Maria Teresa (Hospital Veterinari Sant Mori S.L) ; Cruz, Sílvia (Hospital Veterinari Sant Mori S.L) ; Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol) ; Guallar, Víctor (Catalan Institution for Research and Advanced Studies) ; Vidal Barba, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Valencia, Alfonso (Catalan Institution for Research and Advanced Studies) ; Blanco, Ignacio (Institut Germans Trias i Pujol) ; Blanco, Julià (Institut Germans Trias i Pujol) ; Clotet, Bonaventura (Institut Germans Trias i Pujol) ; Vergara-Alert, Júlia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
COVID-19 is the most devastating pandemic in recent history. As with many emerging infectious diseases, it is of zoonotic origin, meaning that animals played a major role in the initial transmission events. [...]
2020 - 10.1073/pnas.2010817117
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117 (september 2020) , p. 24790-24793  
2021-02-12
12:04
13 p, 3.1 MB Porcine Circovirus 3 Detection in Aborted Fetuses and Stillborn Piglets from Swine Reproductive Failure Cases / Saporiti, Viviane (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Valls, Laura (Laboratorios Hipra, S.A.) ; Maldonado, Jaime (Laboratorios Hipra, S.A.) ; Perez, Mónica (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Correa-Fiz, Florencia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Sibila, Marina (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Porcine circovirus 3 (PCV-3) has been widely detected in healthy and diseased pigs; among different pathologic conditions, the strongest evidence of association comes from reproductive disease cases. [...]
2021 - 10.3390/v13020264
Viruses, Vol. 13 Núm. 2 (2021) , p. 264  
2021-02-01
13:07
20 p, 745.4 KB Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach / Bosch-Camós, Laia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Navas, María Jesús (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Pina-Pedrero, Sonia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Accensi Alemany, Francesc (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Correa-Fiz, Florencia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Park, Chankyu (Konkuk University. Department of Stem Cells and Regenerative Biology) ; Carrascal Pérez, Montserrat (Instituto de Investigaciones Biomédicas de Barcelona. Unidad de Espectrometría de Masas Biológica y Proteómica) ; Domínguez, Javier (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria. Departamento de Biotecnología) ; Salas, María Luisa (Universidad Autónoma de Madrid. Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas) ; Nikolin, Veljko (Boehringer Ingelheim Veterinary Research Center) ; Collado, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rodríguez, Fernando (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; López Fernandez, Elisabet (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
The development of subunit vaccines against African swine fever (ASF) is mainly hindered by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in protection. As a good example, the identity of ASFV-specific CD8+ T-cell determinants remains largely unknown, despite their protective role being established a long time ago. [...]
2021 - 10.3390/vaccines9010029
Vaccines, Vol. 9 Núm. 1 (2021) , p. 29  
2021-02-01
03:54
14 p, 7.6 MB Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8 / Sánchez-Carvajal, Jose María (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Ruedas-Torres, Inés (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Carrasco, Librado (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Pallarés, Francisco José (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Rodríguez-Gómez, Irene Magdalena (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology, Faculty of Veterinary Medicine) ; Gómez-Laguna, Jaime (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology)
PRRSV-1 virulent strains cause high fever, marked respiratory disease and severe lesions in lung and lymphoid organs. Regulated cell death (RCD), such as apoptosis, necroptosis and pyroptosis, is triggered by the host to interrupt viral replication eliminating infected cells, however, although it seems to play a central role in the immunopathogenesis of PRRSV, there are significant gaps regarding their sequence and activation upon PRRSV-infection. [...]
2021 - 10.1186/s13567-020-00882-x
Veterinary research, Vol. 52 (january 2021)  
2021-01-19
11:49
16 p, 20.5 MB Immunogenicity and Protection against Mycobacterium caprae Challenge in Goats Vaccinated with BCG and Revaccinated after One Year / Arrieta Villegas, Claudia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Martin, Maite (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Verdés Martinez, Judit (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Espada, Yvonne (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Singh, Mahavir (LIONEX Diagnostics and Therapeutics GmbH) ; Villarreal Ramos, Bernardo (Animal Health and Veterinary Laboratories Agency. TB Research Group) ; Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Pérez de Val, Bernat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Vidal Barba, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Vaccination has been proposed as a supplementary tool for the control of tuberculosis in livestock. The long-term immunogenicity elicited by bacillus Calmette-Guerin (BCG) and the efficacy of revaccination were investigated in thirty goat kids distributed into three groups: unvaccinated controls, BCG (vaccinated at week 0) and BCG-BCG (vaccinated at weeks 0 and 56). [...]
2020 - 10.3390/vaccines8040751
Vaccines, Vol. 8 Núm. 4 (2020) , p. 751  
2021-01-11
03:47
15 p, 664.8 KB Biosecurity in pig farms : a review / Alarcón, Laura Valeria (Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias) ; Allepuz Palau, Alberto (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
The perception of the importance of animal health and its relationship with biosecurity has increased in recent years with the emergence and re-emergence of several diseases difficult to control. This is particularly evident in the case of pig farming as shown by the recent episodes of African swine fever or porcine epidemic diarrhoea. [...]
2021 - 10.1186/s40813-020-00181-z
Porcine Health Management, Vol. 7 (january 2021)