Centre de Recerca en Sanitat Animal (CReSA-IRTA)


The Centre de Recerca en Sanitat Animal (CReSA) is the animal health research program of Institut de Recerca i Tecnologia Agroalimentàries (IRTA), its hosting institution. IRTA is a research institute owned by the Government of Catalonia (Spain) ascribed to the Department of Agriculture, Livestock, Fisheries and Food (DARP), which is also a CERCA institute.

CReSA activity is executed at the Edifici CReSA, which is a technologically advanced building, with conventional laboratories as well as biocontainment with level-3 biosafety (BSL-3) laboratories and animal facilities. CReSA is located within the campus of the UAB (Barcelona, Spain).

CReSA together with the BSL3 infrastructure of Centro de Investigación en Sanidad Animal (CISA-INIA), configures the so-called Red de Laboratorios de Alta Seguridad Biológica (RLASB, www.rlasb.es , High Biological Security Laboratories Network). The RLASB is a singular scientific and technological infrastructure (ICTS) of the Spanish Government. CReSA is also participating in the Red de Laboratorios de Alerta Biológica (RE-LAB, Biological Alert Laboratory Network), at Spanish level, and is one of the corner-stones of animal disease surveillance for the Catalan government. Recently, CReSA has been recognized as OIE Collaborating Centre for research and control for emerging and re-emerging swine diseases in Europe and OIE Reference Centre for Classical Swine Fever.

The research at CReSA is being performed under the umbrella of three major activities: basic and applied independent research based on national and international projects (organized in 3 research subprograms on epidemiology and risk assessment, endemic diseases and transboundary diseases), services for public administrations and research contracts with agri-food sector companies.

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2019-04-02
16:54
20 p, 11.0 MB Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection / Almansa, Raquel (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis) ; Martínez-Orellana, Pamela (Universitat Autónoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Rico, Lucía (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis) ; Iglesias, Verónica (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis) ; Ortega, Alicia (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis) ; Vidaña, Beatriz (Department of Pathology. Animal and Plant Health Agency) ; Martínez Martínez, Jorge (Universitat Autónoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Expósito, Ana (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis) ; Montoya, Maria (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Bermejo-Martin, Jesús F. (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Background: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. [...]
2017 - 10.7717/peerj.3915
PeerJ, Vol. 2017, Núm. 10 (2017) , p. e3915  
2019-04-01
17:54
13 p, 3.2 MB Expression dynamics of innate immunity in influenza virus-infected swine / Montoya, Maria (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Foni, Emanuela (OIE Reference Laboratory for Swine Influenza. Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna) ; Solórzano, Alicia (The State University of New Jersey. Public Health Research Institute and Regional Biocontainment Laboratory) ; Razzuoli, Elisabetta (S.S. Sezione Genova. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta) ; Baratelli, Massimiliano (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Bilato, Dania (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna. Laboratory of Cellular Immunology) ; Córdoba, Lorena (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; del Burgo, Maria Angeles Martín (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departmento de Biotecnología) ; Martinez, Jorge (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ; Martinez-Orellana, Pamela (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Chiapponi, Chiara (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna. OIE Reference Laboratory for Swine Influenza) ; Perlin, David S. (The State University of New Jersey. Public Health Research Institute and Regional Biocontainment Laboratory) ; del Real, Gustavo (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departmento de Biotecnología) ; Amadori, Massimo (Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna. Laboratory of Cellular Immunology)
The current circulating swine influenza virus (IV) subtypes in Europe (H1N1, H1N2, and H3N2) are associated with clinical outbreaks of disease. However, we showed that pigs could be susceptible to other IV strains that are able to cross the species barrier. [...]
2017 - 10.3389/fvets.2017.00048
Frontiers in Veterinary Science, Vol. 4, Núm. 48 (21 April 2017)  
2019-03-04
15:33
3 p, 708.0 KB Schmallenberg Virus Circulation in High Mountain Ecosystem, Spain / Fernández-Aguilar, Xavier (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Pujols, Joan (Fundació Centre de Recerca en Sanitat Animal) ; Velarde, Roser (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Rosell, Rosa (Universitat Autònoma de Barcelona. Departament de Cirurgia) ; López-Olvera, Jorge Ramón (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Marco Sánchez, Ignasi (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ; Lavín González, Santiago (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Cabezón, Óscar (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
2014 - 10.3201/eid2006.130961
Emerging Infectious Diseases, Vol. 20 Núm. 6 (2014)  
2019-01-21
17:00
16 p, 3.9 MB Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep / Balseiro, Ana (SERIDA. Servicio Regional de Investigación y Desarrollo Agroalimentario. Centro de Biotecnología Animal) ; Altuzarra, Raúl (Universitat Autònoma de Barcelona. Departament de Medicina i Cirugia Animals) ; Vidal Barba, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirugia Animals) ; Espada Gerlach, Yvonne (Universitat Autònoma de Barcelona. Departament de Medicina i Cirugia Animals) ; Sevilla, Iker A. (NEIKER-Tecnalia. Instituto Vasco de Investigación y Desarrollo Agrario. Departamento de Sanidad Animal) ; Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Medicina i Cirugia Animals) ; Garrido, Joseba M. (NEIKER-Tecnalia. Instituto Vasco de Investigación y Desarrollo Agrario. Departamento de Sanidad Animal) ; Juste, Ramón A. (SERIDA. Servicio Regional de Investigación y Desarrollo Agroalimentario. Centro de Biotecnología Animal) ; Prieto, Miguel (SERIDA. Servicio Regional de Investigación y Desarrollo Agroalimentario. Centro de Biotecnología Animal) ; Pérez De Val, Bernat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Animal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. [...]
2017 - 10.1371/journal.pone.0180546
PLoS ONE, Vol. 12 Núm. 7 (july 2017) , p. e0180546  
2019-01-21
13:54
18 p, 10.4 MB Long-term dynamics of Mycoplasma conjunctivae at the wildlife-livestock interface in the Pyrenees / Fernández-Aguilar, Xavier (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Frey, Joachim (University of Bern. Institute of Veterinary Bacteriology) ; Velarde, Roser (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Serrano Ferron, Emmanuel (Universidad de Aveiro . Departamento de Biologia and Cesam) ; Colom Cadena, Andreu (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Gelormini, Giuseppina (University of Bern. Institute of Veterinary Bacteriology) ; Marco Sánchez, Ignasi (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Mentaberre García, Gregorio (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; Lavín González, Santiago (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ; López Olvera, Jorge R. (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge (SEFaS). Departament de Medicina i Cirurgia) ; Cabezón Ponsoda, Óscar (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Functional roles of domestic and wild host populations in infectious keratoconjunctivitis (IKC) epidemiology have been extensively discussed claiming a domestic reservoir for the more susceptible wild hosts, however, based on limited data. [...]
2017 - 10.1371/journal.pone.0186069
PLoS ONE, Vol. 12 Núm. 10 (october 2017) , p. e0186069  
2019-01-17
18:28
14 p, 2.7 MB Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats / Arrieta Villegas, Claudia (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Perálvarez, Tania (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Vidal, Enric (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Puighibet Maso, Zöe (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Canturri, Albert (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Sevilla, Iker A. (NEIKER-Tecnalia. Instituto Vasco de Investigación y Desarrollo Agrario. Departamento de Sanidad Animal) ; Espada Gerlach, Yvonne (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Juste, Ramón A. (SERIDA. Servicio Regional de Investigación y Desarrollo Agroalimentario. Centro de Biotecnología Animal) ; Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ; Pérez De Val, Bernat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. [...]
2018 - 10.1371/journal.pone.0196948
PLoS ONE, Vol. 13 Núm. 5 (may 2018) , p. e0196948  
2019-01-15
13:37
20 p, 5.8 MB Morbidity, outcomes and cost-benefit analysis of wildlife rehabilitation in Catalonia (Spain) / Molina-López, Rafael Ángel (Centre de Fauna Salvatge de Torreferrussa) ; Mañosa, Santi (Universitat de Barcelona. Departament de Biologia evolutiva. Institut de Recerca de la Biodiversitat) ; Torres-Riera, Alex (Universitat de Barcelona. Departament de Biologia evolutiva. Institut de Recerca de la Biodiversitat) ; Pomarol, Manel (Centre de Fauna Salvatge de Torreferrussa) ; Darwich Soliva, Laila (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Background There are few studies of careful examination of wildlife casualties in Wildlife Rehabilitation Centers. These studies are essential for detecting menaces to wild species and providing objective criteria about cost-benefit of treatments in those centers. [...]
2017 - 10.1371/journal.pone.0181331
PLoS ONE, Vol. 12 Núm. 7 (july 2017) , p. e0181331  
2018-06-18
04:06
13 p, 2.0 MB A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting / Chrun, Tiphany (Université Paris-Saclay.Unité de recherche virologie et immnunologie moléculaires (VIM-INRA)) ; Lacôte, Sandra (ANSES-Laboratoire de Lyon. Unité Virologie) ; Urien, Céline (Université Paris-Saclay. Unité de recherche virologie et immnunologie moléculaires (VIM-INRA)) ; Jouneau, Luc (Université Paris-Saclay. Unité de recherche virologie et immnunologie moléculaires (VIM-INRA)) ; Barc, Céline (Plate-Forme d'Infectiologie Expérimentale (PFIE). UE1277-INRA) ; Bouguyon, Edwige (Université Paris-Saclay. Unité de recherche virologie et immnunologie moléculaires (VIM-INRA)) ; Contreras, Vanessa (CEA-Université Paris Sud-INSERM. Hôpital du Kremlin Bicêtre. France) ; Ferrier-Rembert, Audrey (Institut de Recherche Biomédicale des Armées (IRBA). France) ; Peyrefitte, Christophe N. (Institut de Recherche Biomédicale des Armées (IRBA). France) ; Busquets i Martí, Núria (Fundació Centre de Recerca en Sanitat Animal) ; Vidal Barba, Enric (Universitat Autònoma de Barcelona. Fundació Centre de Recerca en Sanitat Animal) ; Pujols, Joan (Fundació Centre de Recerca en Sanitat Animal) ; Marianneau, Philippe (ANSES-Laboratoire de Lyon. Unité Virologie) ; Schwartz-Cornil, Isabelle (Université Paris-Saclay. Unité de recherche virologie et immnunologie moléculaires (VIM-INRA))
Rift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent vectors are present, vaccine development is an urgent priority as no licensed vaccines are available outside areas of endemicity. [...]
2018 - 10.1038/s41541-018-0052-x
NPJ Vaccines, Vol. 3 (April 2018) , article 14  
2018-04-09
04:15
17 p, 2.0 MB Limited Interactions between Streptococcus Suis and Haemophilus Parasuis in In Vitro Co-Infection Studies / Mathieu-Denoncourt, Annabelle ; Letendre, Corinne ; Auger, Jean-Philippe ; Segura, Mariela ; Aragon, Virginia (Fundació Centre de Recerca en Sanitat Animal) ; Lacouture, Sonia ; Gottschalk, Marcelo
Streptococcus suis and Haemophilus parasuis are normal inhabitants of the porcine upper respiratory tract but are also among the most frequent causes of disease in weaned piglets worldwide, causing inflammatory diseases such as septicemia, meningitis and pneumonia. [...]
2018 - 10.3390/pathogens7010007
Pathogens, Vol. 7 (january 2018)  
2018-02-08
08:22
8 p, 465.3 KB Protective effect of a polyvalent influenza DNA vaccine in pigs / Karlsson, Ingrid ; Borggren, Marie ; Rosenstierne, Maiken Worsøe ; Trebbien, Ramona ; Williams, James A. ; Vidal, Enric (Fundació Centre de Recerca en Sanitat Animal) ; Vergara-Alert, Júlia (Fundació Centre de Recerca en Sanitat Animal) ; Solanes Foz, David (Fundació Centre de Recerca en Sanitat Animal) ; Darji, Ayub (Fundació Centre de Recerca en Sanitat Animal) ; Sisteré-Oró, Marta (Fundació Centre de Recerca en Sanitat Animal) ; Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ; Nielsen, Jens ; Fomsgaard, Anders
Influenza A virus in swine herds represents a major problem for the swine industry and poses a constant threat for the emergence of novel pandemic viruses and the development of more effective influenza vaccines for pigs is desired. [...]
2018 2018 - 10.1016/j.vetimm.2017.11.007
Veterinary Immunology and Immunopathology, Vol. 195 (january 2018) , p. 25-32